Yocum scored three times and Romanelli twice, and Mark Rodgers led the Mustangs with 79 of the team's 190 rushing yards. Smith was 19-of-24 for 231 yards passing. Johnson finished with eight receptions for 115 yards.
John Kelly threw three touchdown passes for St. Francis (1-7).
Before the game, survivors of the Cal Poly plane crash that occurred 50 years ago Friday were honored. The crash on Oct. 29, 1960 in Toledo, Ohio, killed 22 people, including 16 Mustang players.