The Blue Devils (2-2) surpassed their previous scoring average of 18.3 points per game with 21 in the first quarter, when Thompson rushed for both of his touchdowns.
Quarterback Sean Renfree completed 21 of 30 passes for 278 yards and a touchdown for the Blue Devils. His 7-yard scramble late in the third quarter gave Duke a 45-13 lead.
Duke outgained the Green Wave (2-2) 336 yards to 127 in the first half. The only touchdown until the fourth quarter for Tulane, which scored 49 points last week in a win over UAB, came on Ryan Travis' 23-yard interception return in the first quarter.
Duke's defense, which shut out Boston College in the second half of a 20-19 win last week, had put together a streak of five quarters without allowing a touchdown.
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Of the 51 SEC players drafted by NFL teams over the weekend, 25 were ranked in the ESPN 300 or the ESPN JC 100.
Spring practice is over, but the QB competition will rage through the summer at Rutgers.
Just 10 years ago, the Crimson Tide football program was mired in mediocrity. But a big turnaround in Tuscaloosa was just around the corner.
Iain O'Brien and Dirk Nannes go through the teams at the halfway mark to see who are overachieving, underachieving or going right on track.
Now that spring football is in the rearview mirror, we're taking a team-by-team look in the ACC's Atlantic to see what we know and what we don't.
Quarterback Kurt Benkert announced that he will transfer to Virginia, where he will be eligible to play immediately and will have two years of eligibility.