The Hawkeyes (3-1) now enter Big Ten play with a three-game winning streak, their longest since 2010.
Martin-Manley scored on returns of 83 and 63 yards early in the second quarter as Iowa jumped out to a 38-3 halftime lead.
Lowery took back picks for 35 and 13-yard TDs for Iowa, which scored its most points since it had 62 against Northwestern in 2002.
Tyler Van Tubbergen had 114 yards passing for the Broncos (0-4).
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A final decision in Ohio State's quarterback derby won't be revealed until just before the season kicks off, but Urban Meyer isn't ruling out playing both his decorated candidates.
Sales of beer with Joe Paterno's name on it are so brisk that the company that makes it is gearing up for a second run after just a week on the shelves.
Baylor coach Art Briles said Monday his fourth-ranked Bears have not been distracted by the swirling controversy surrounding the program's handling of former defensive end Sam Ukwuachu.
Junior transfer Chad Kelly, the nephew of NFL Hall of Famer Jim Kelly, will start at quarterback for Ole Miss in the Rebels' opener against Tennessee Martin on Saturday.
Florida linebacker Antonio Morrison, who injured his left knee in January and needed two surgeries to repair the damage, will play in Saturday's opener against New Mexico State.
Middle Tennessee coach Rick Stockstill has named his son, redshirt freshman Brent Stockstill, his starting quarterback for the Blue Raiders' season opener against Jackson State.