The Hawkeyes (3-1) now enter Big Ten play with a three-game winning streak, their longest since 2010.
Martin-Manley scored on returns of 83 and 63 yards early in the second quarter as Iowa jumped out to a 38-3 halftime lead.
Lowery took back picks for 35 and 13-yard TDs for Iowa, which scored its most points since it had 62 against Northwestern in 2002.
Tyler Van Tubbergen had 114 yards passing for the Broncos (0-4).
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On Nov. 27, 2010, Oklahoma State's Brodrick Brown gave new meaning to the tip drill when he leaped out of bounds to deflect the ball back into play, where LB Shaun Lewis completed the improbable interception.
From the Mets making the World Series to Michigan State defeating Michigan, the First Take Thanksgiving crew share the sports moments that they are most thankful for this year.
Chris Petersen is now under contract with Washington through the 2020 season after the coach received a two-year extension Thursday.
Trevor Matich examines what went wrong on offense in Ohio State's loss to Michigan State and what the Buckeyes need to do to execute against Michigan.
Oklahoma running back Samaje Perine is the winner of the Capital One Cup Impact Performance of the Week.
Texas A&M offensive coordinator Jake Spavital breaks down film of key offensive plays from Texas A&M vs. Vanderbilt.