UConn turned the ball over five times and remains winless through four games. The Huskies struggled to find any offense behind quarterback Chandler Whitmer, increasing the pressure on third-year Connecticut head coach Paul Pasqualoni.
Buffalo (2-2) scored through the air, on the ground and on defense in building a 28-12 halftime lead. They blocked a field goal and scored 17 points off Connecticut turnovers.
Bulls quarterback Joe Licata passed for a career-high three touchdowns, connecting with different receivers on each score. Licata found tight end Mason Schreck for a 5-yard touchdown in the first quarter, later adding a 22-yard touchdown to Alex Neutz and a 36-yard score to Fred Lee.
The Bulls were aided by the return of starting running back Branden Oliver, who had 110 total yards including 90 yards rushing and a touchdown.
Whitmer turned the ball over four times, including a second-quarter interception that Najja Johnson returned 33 yards for a Bulls touchdown.