Facing an early 3-0 deficit, the Cowboys (7-1, 3-0 Southland) scored touchdowns on three straight drives as Cody Stroud hit Diontae Spencer for a 5-yard score and Dylan Long had touchdown runs of 2 and 4.
Wiltz ran for touchdowns of 17 and 5 in the third quarter. Following a 4-yard score from Henderson to Buchanan, McNeese State's Khalil Thomas returned the ensuing kickoff 94 yards for a touchdown to fuel the rout.
Wiltz finished with 98 yards rushing on 14 carries. Kelvin Bennett ran for 169 yards on 13 attempts.