Jeter was replaced by reserve infielder Ramiro Pena after reaching base on a single up the middle with one out in the seventh inning of the Yankees' 11-2 win.
The Yankees' captain was hit by a pitch on the back of his left thigh in the second inning and his left hamstring subsequently "stiffened up," according to Yankees manager Joe Girardi.
"We won't really know [until] tomorrow," Girardi said when asked about the extent of Jeter's injury. "He got hit in the back of the hamstring and it stiffened up."
Jeter walked gingerly down the first-base line after getting hit by a 90-mph Mitch Talbot fastball and was accompanied by Girardi, first-base coach Mick Kelleher and trainer Gene Monahan.
Jeter, who was unavailable for comment after the game, finished 2-for-3 on Monday and extended his hitting streak to eight games. The shortstop, who leads all active players with 2,814 career hits, is hitting .302 on the year and is 17-for-35 in his last seven games.
Ian Begley is a contributor to ESPNNewYork.com.