Santana was lifted after the fifth inning and the Mets trailing 6-0. He allowed six runs on seven hits, striking out five and walking one. Santana threw 86 pitches.
After the first no-hitter in Mets history, manager Terry Collins gave Santana two extra days rest to protect his surgically repaired left shoulder.
Johnny Vander Meer remains the only major leaguer to throw consecutive no-hitters, accomplishing the feat in 1938 with Cincinnati.
Information from The Associated Press was used in this report.