Lopez resprained his left ankle in the third quarter of Thursday night's game against the Los Angeles Clippers. He returned briefly before trainer Tim Walsh decided Lopez's night was finished for good.
Lopez missed seven games earlier in the season after originally suffering the injury in Phoenix on Nov. 15.
Lopez, 25, is averaging 20.5 points, 6.0 rebounds and 1.9 blocks per game. He ranks third in the NBA in player efficiency rating behind only the Miami Heat's LeBron James and the New Orleans Pelicans' Anthony Davis.