Chandler did not travel with the team to Philadelphia for its game against the Philadelphia 76ers.
Coach Mike Woodson said Chandler is "a little better" but his status for Monday's game against Phoenix is uncertain.
The Knicks will also be without point guard Beno Udrih on Saturday. Udrih suffered a knee injury in the team's win against Detroit on Tuesday. An MRI taken Wednesday revealed that Udrih has inflammation of the left tibiofibular joint.
With Udrih out, rookie Toure' Murry likely will play more minutes at backup point guard.
The Knicks (13-22) will count on Kenyon Martin to fill in at center with Chandler out.
Chandler first came down with the illness on Sunday. He left the Knicks' game against Dallas that night in the first quarter and has not practiced or played since.