Humphries had missed the past two games with a sprained left ankle.
"Everybody's available. Hump looked good, he went through the whole practice yesterday, he looked pretty good and he's available," Carlesimo said. "I'm not thrilled because he missed a bunch of time.
"I don't want to say he's definitely going to be in there, but there's no reason for me not to use him. If I don't use him, it's just because of rotations or whatever, but he's available, and I would expect that he probably will play."
Humphries, 27, is averaging 7.2 points and 7.3 rebounds in 27 games.
Veteran reserve Jerry Stackhouse, who missed Monday's practice because of a personal matter, will not play, Carlesimo said.
Mike Mazzeo is a regular contributor to ESPNNewYork.com.