Both Giants were listed as questionable entering the game. Nicks, the Giants top offensive playmaker, has a bone bruise and hyper-extended knee. Tuck made his season debut after missing last week's game due to pain in his neck.
During individual warm-ups, Nicks looked good, running a 40-yard route and catching several short passes from Eli Manning.
Nicks had three receptions for 15 yards and a touchdown. Tuck collected 1½ sacks.
Jackson strained his right quadriceps on a 47-yard scoring run on the Rams' first offensive play of the season during Sunday's loss to the Eagles.
Shortly before Nicks tested his leg, Jackson tried to see what he could do on his injured quad. He did several high-stepping and kicking exercises but when he got into a sprinter's stance and ran 40 yards, the Rams running back just didn't show the type of explosion that he normally does.
Defensive end Osi Umenyiora, tight end Travis Beckum, cornerback Prince Amukamara, running back Da'Rel Scott, wide receiver Jerrel Jernigan, offensive guard Mitch Petrus and offensive tackle James Brewer were inactive for the Giants.
Ohm Youngmisuk covers the Giants for ESPNNewYork.com. Information from The Associated Press contributed to this report.