Tuck underwent an MRI on his toe this week and was limited in practice on Friday, but was apparently good enough to go in what will be another pivotal matchup for the Giants (7-6) as they look to stay on top in the NFC East. It is unknown how many snaps he'll be able to play, though.
The 28-year-old Tuck, who serves as the Giants' defensive captain, suffered the injury last Sunday night in Dallas, but did not recall when it occurred. He had been listed as questionable on the official injury report.
Tuck has appeared in just nine games this season because of groin and neck injuries. He has 24 tackles and three sacks in what has been an underwhelming year for the seven-year pro, who was coming off a Pro Bowl campaign in 2010 in which he amassed 11.5 sacks and forced six fumbles.
Defensive end Osi Umenyiora (ankle/knee) missed his third straight game.
Smith, who had been splitting snaps in practice this week, went against Giants right end Jason Pierre-Paul, the NFC defensive player of the week.
Also inactive for the Giants on Sunday were cornerback Derrick Martin (back), tight end Travis Beckum (chest), linebacker Mark Herzlich (ankle), center David Baas (neck), defensive tackle Jimmy Kennedy and offensive lineman James Brewer.
Baas and Herzlich both missed their third straight game.
Mike Mazzeo is a regular contributor to ESPNNewYork.com. Information from The Associated Press was used in this report.