With 4:16 remaining before halftime, linebacker Rey Maualuga was carted off with what the Bengals diagnosed as a left knee injury.
After initially being listed as questionable to return with a knee injury, Maualuga was ruled out when the Bengals learned he also suffered a concussion.
Maualuga was one of three Bengals players who suffered injuries in the final minutes of the first half.
Maualuga's injuries came when he tried to plug a hole through which Jets running back Chris Ivory which trying to sprint. On a third-and-1, Maualuga stepped up and collided with Ivory. Immediately after the 2-yard, first-down run, Maualuga's body appeared to fall limp as if he had a serious injury. His helmet was immediately removed as trainers came out to evaluate him.
About three minutes after the play, a cart came onto the field. With his teammates huddled around him, Maualuga got to his feet and was eased onto the bed of the cart with their support.
Defensive tackle Domata Peko was among those who helped Maualuga. He pounded the linebacker's shoulder pad before the cart drove off. Before disappearing into the home-team tunnel, Maualuga waved twice to fans.
This is the second time in as many weeks that Maualuga has left a game. He suffered a hamstring injury in the fourth quarter of last week's game at Detroit but only missed one day of practice last week.
Just after losing Maualuga, the Bengals also lost left tackle Andrew Whitworth. The Pro Bowl lineman went out with a knee injury and was declared questionable for return. It wasn't readily clear which knee was injured, but Whitworth had surgery on his left knee after a midseason injury last year.
On the final play of the first half, defensive back Taylor Mays also left the game with a right shoulder injury. He was still getting tended to on the field after players from both teams had jogged into their locker rooms at the half.
The news wasn't all bad for the Bengals, who picked up a 49-9 victory on the day.