Henry is the No. 1 tight end on Mel Kiper's Big Board. He led all SEC tight ends with 51 catches for 739 yards and three touchdowns and won the John Mackey Award, honoring the nation's tight top tight end at the end of the season.
The Arkansas native wrote a letter to Razorback fans about his decision.
"After a great deal of prayer and reflection, I have made the very difficult decision to pursue my childhood dream and enter the 2016 NFL Draft," Henry wrote.
"I have grown so much as a person and player these past three years at the University of Arkansas. I have enjoyed my experience more than I could have ever imagined."
Kirkland announced his decision shortly after Henry. Though he moved to left tackle this past season, the 6-foot-5, 340-pound Razorback is ranked as the No. 5 offensive guard by Kiper.
— 55 (@15HARLEM_BOSKI) January 4, 2016
All eyes are now on running back Alex Collins. Many have speculated that Collins will join his teammates and leave school early, but Arkansas coach Bret Bielema said he plans to have lunch with Collins on Wednesday at his home in Florida, and a decision will come after that.
Collins rushed for 185 yards and three touchdowns in the bowl game.