Schobel missed his first game since entering the league in 2001 -- a span of 117 straight games -- because of a ligament and bone problem in his left foot. He was one of three active defensive ends (Kevin Carter and Terrell Suggs) to have never missed a career game.
Schobel has one sack in five games.
Bills starting center Melvin Fowler (elbow) and starting cornerback Terrence McGee (left knee sprain) were also inactive. Rookie cornerback Leodis McKelvin started his first game in place of McGee, who missed his second consecutive game.
The Bills welcomed back receiver/punt returner Roscoe Parrish after he missed two games because of a thumb injury that required surgery.
San Diego was missing receiver Chris Chambers, who sprained his left ankle against the Miami Dolphins two weeks ago. He missed last Sunday's win over the New England Patriots. In five games this season, Chambers has just 11 receptions, but five of them have gone for touchdowns.
Chargers linebacker Jyles Tucker missed his third game because of a hamstring injury.