Wood agreed to a five-year deal, but terms were being finalized Tuesday night so that he could report to camp. His agreement ends a five-day holdout and leaves the Bills with two unsigned draft choices -- first-rounder Aaron Maybin and second-rounder Jarius Byrd.
The 6-3, 309-pound Wood becomes the fifth first-rounder to reach an agreement. Once he reports, Wood is expected to compete for a starting job at right guard on a completely revamped line that's expected to feature two rookie starters and no returning players at the same position.
Wood has spent the past week in Buffalo waiting for negotiations to end so he can report to camp 90 minutes away in suburban Rochester.
Wood is the second of Buffalo's two first-round picks. He was chosen with the 28th overall pick out of Louisville. He started 49 straight games in college at center and was a Big East Conference first-team selection last season.
The Bills intend to convert Wood into a guard, and are counting on him to take over for Brad Butler, who's being shifted to right tackle. Langston Walker is switching to left tackle, after two-time Pro Bowl center Jason Peters was traded to Philadelphia. The Bills signed Geoff Hangartner in free agency to take over at center, while rookie second-round pick Andy Levitre is competing to start at left guard.
Wood has so far missed six practices since the team opened camp Saturday.
Reserve defensive tackle John McCargo missed practice Tuesday night because of a hamstring injury, which Jauron described as minor. Starting defensive tackle Marcus Stroud returned to practice after missing two days with a hamstring injury.
Information from The Associated Press was used in this report.