Wayne and running back Donald Brown (sprained shoulder) both were sidelined in the second quarter Sunday and the team said it was questionable whether they would return.
Wayne had six receptions for 76 yards and a 6-yard touchdown before leaving with a strained groin muscle. He caught four passes for 61 yards on the opening possession.
Brown, Joseph Addai's backup, had two carries for 58 yards. He broke a 45-yarder in the first quarter.