DeAngelo Williams, Jonathan Stewart and Tyrell Sutton all missed practice again Friday with injuries and won't play against the Buccaneers. Goodson will be promoted to starter for the NFL's 26th-ranked rushing unit.
Goodson has 99 yards rushing and no touchdowns in two NFL seasons. Behind him are Josh Vaughan, a rookie signed Tuesday, and Andre Brown, who was claimed off waivers from Indianapolis this week.
It gives rookie quarterback Jimmy Clausen little certainty in the run game as he makes his fourth start for the Panthers (1-7).
Carolina has also signed quarterback Brian St. Pierre to the practice squad and released linebacker Sean Ware.