Both will look to take better care of the ball in Sunday's meeting in Tampa Bay.
The Bills (4-8), who are 1-4 on the road, coughed up the ball on their final two possessions of Sunday's 34-31 overtime loss to Atlanta in Toronto, all but guaranteeing their NFL-worst 14th straight season without a postseason appearance.
A 14-yard pass from E.J. Manuel to Stevie Johnson would have set up Buffalo on Atlanta's 30-yard line with less than 30 seconds to play in regulation, but Johnson fumbled. Tight end Scott Chandler followed that by fumbling on the second play of scrimmage in overtime, leading to Atlanta's game-winning field goal.
It was the Bills' fourth loss in five games and fourth defeat this season by seven points or fewer.
"We've got to learn how to win close games. We've got to learn how to win games on the road. We've got to finish teams," coach Doug Marrone said on Monday. "It was tough this morning. It's tough to swallow."
Buffalo is tied with Tampa Bay -- and Houston -- for the league's most losses via blown leads with seven.
The Buccaneers (3-9) had seemed to turn a corner with three straight wins following an 0-8 start, but last Sunday's 26-7 setback at Carolina guaranteed Tampa Bay a third consecutive losing season.
The Buccaneers finished with 206 yards of offense, their fewest since gaining 166 in a loss at Dallas on Sept. 23, 2012. Coach Greg Schiano didn't think facing Carolina's top-ranked scoring defense was a valid excuse.
"They're playing at a high level right now, yet I thought there were plenty of opportunities, especially early in the game to kind of set the course of the game where we'd be able to make it a fourth-quarter game," he said. "We didn't take advantage of it."
At the crux of Tampa Bay's problems was an ineffective performance from rookie quarterback Mike Glennon, who seemed to regress a bit. In making his ninth start, Glennon failed to throw a touchdown for the first time and was intercepted and lost a fumble, marking his first multi-turnover performance since his first start on Sept. 29 against Arizona.
"He did some things (Sunday) that he hasn't done," said Schiano, whose team has won two in a row at Raymond James Stadium after starting 0-4 there. "I think part of it has to do with the defense. He was trying to make something happen."
Another part of Glennon's struggles might have been the lack of a running game. The Buccaneers were held to 66 yards on the ground a week after being limited to a season-low 22 against Detroit. They had averaged 177.0 yards in the three previous games.
Tampa Bay might find it much easier to run against a Buffalo defense that gave up 151 rushing yards to Atlanta, which owns one of the league's worst running games.
The Bills' own ground attack came alive for 195 yards against the Falcons after gaining 95 yards or fewer in four of their previous five games. C.J. Spiller ran 15 times for a season-high 149 yards after totaling 29 in his previous two contests.
"It was great, but like I said going in to the game, each week is different," Spiller told the team's website. " ... Just had another good running day, but this team (Tampa Bay) is going to be ready and you can take some good away from the tape and see what you've done well, but we just have to take what they give us."
Tampa Bay has allowed an average of 139.7 rushing yards in its last three games.
The Buccaneers are hopeful Darrelle Revis will be able to play after he practiced Wednesday. He left Sunday's contest with what Schiano described as an "upper torso" injury.
Tampa Bay owns a 6-3 all-time series edge, though Buffalo claimed a 33-20 home victory in the last meeting in 2009. Fred Jackson, who is 136 yards shy of joining Thurman Thomas and O.J. Simpson as the only players in team history with 5,000 rushing yards, ran for 163 yards on 28 carries.