2012 Regular Season NFL Leaders
| RK | PLAYER | RESULT | PASS EPA | RUN EPA | SACK EPA | PEN EPA | TOTAL EPA | ACT PLAYS | QB PAR | QB PAA | TOTAL QBR |
| 1 | Peyton Manning, DEN | W 31-19 vs PIT in Wk 1 | 13.1 | 0.9 | -1.7 | 0.5 | 12.8 | 32 | 9.5 | 6.9 | 94.4 |
| 2 | Matt Ryan, ATL | W 40-24 @ KC in Wk 1 | 12.5 | 4.9 | -1.1 | -0.5 | 15.7 | 36 | 13.0 | 10.0 | 97.5 |
| 3 | Tony Romo, DAL | W 24-17 @ NYG in Wk 1 | 12.0 | 1.1 | -1.6 | -1.7 | 9.7 | 45 | 9.0 | 5.3 | 82.8 |
| 4 | Joe Flacco, BAL | W 44-13 vs CIN in Wk 1 | 9.9 | -0.7 | -1.6 | 0.7 | 8.3 | 36 | 11.1 | 8.1 | 95.1 |
| 5 | Sam Bradford, STL | L 27-23 @ DET in Wk 1 | 9.4 | -0.5 | -5.4 | -0.8 | 2.7 | 33 | 2.2 | -0.5 | 44.8 |
| 6 | Blaine Gabbert, JAC | L 26-23 @ MIN in Wk 1 | 8.4 | -1.4 | -1.3 | 0.2 | 5.9 | 51 | 5.6 | 1.4 | 58.5 |
| 7 | Alex Smith, SF | W 30-22 @ GB in Wk 1 | 8.2 | -0.1 | -2.3 | 1.6 | 7.4 | 38 | 7.8 | 4.7 | 83.5 |
| 8 | Ben Roethlisberger, PIT | L 31-19 @ DEN in Wk 1 | 8.1 | -0.6 | -3.1 | -0.1 | 4.3 | 57 | 4.2 | -0.5 | 47.3 |
| 9 | Robert Griffin III, WSH | W 40-32 @ NO in Wk 1 | 7.7 | 0.6 | -0.9 | 2.5 | 10.0 | 42 | 12.2 | 8.7 | 93.8 |
| 10 | Christian Ponder, MIN | W 26-23 vs JAC in Wk 1 | 7.6 | -1.2 | -1.9 | -0.2 | 4.4 | 31 | 4.1 | 1.5 | 66.2 |
| RK | PLAYER | RESULT | PASS EPA | RUN EPA | SACK EPA | PEN EPA | TOTAL EPA | ACT PLAYS | QB PAR | QB PAA | TOTAL QBR |
| 11 | Matt Cassel, KC | L 40-24 vs ATL in Wk 1 | 7.3 | 1.7 | -1.9 | 0.0 | 7.1 | 39 | 8.8 | 5.6 | 87.0 |
| 12 | Tom Brady, NE | W 34-13 @ TEN in Wk 1 | 7.0 | -0.2 | -1.1 | 0.0 | 5.7 | 33 | 8.3 | 5.6 | 90.4 |
| 13 | Carson Palmer, OAK | L 22-14 vs SD in Wk 1 | 6.4 | -0.3 | -0.8 | 2.0 | 7.3 | 57 | 8.7 | 4.0 | 71.5 |
| 14 | Matthew Stafford, DET | W 27-23 vs STL in Wk 1 | 6.2 | 0.0 | -1.3 | 0.5 | 5.3 | 50 | 4.3 | 0.2 | 51.2 |
| 15 | Philip Rivers, SD | W 22-14 @ OAK in Wk 1 | 6.0 | 0.0 | -1.0 | 0.7 | 5.7 | 38 | 5.7 | 2.5 | 70.7 |
| 16 | Mark Sanchez, NYJ | W 48-28 vs BUF in Wk 1 | 5.9 | 0.0 | 0.0 | 0.5 | 6.5 | 30 | 10.5 | 8.0 | 97.1 |
| 17 | Matt Schaub, HOU | W 30-10 vs MIA in Wk 1 | 5.9 | -0.4 | -1.4 | 0.8 | 4.8 | 36 | 5.7 | 2.7 | 73.4 |
| 18 | Aaron Rodgers, GB | L 30-22 vs SF in Wk 1 | 5.3 | 0.8 | -2.3 | 0.7 | 4.6 | 63 | 6.2 | 1.0 | 55.1 |
| 19 | Kevin Kolb, ARI | W 20-16 vs SEA in Wk 1 | 5.1 | 0.0 | 0.0 | 0.8 | 5.8 | 10 | 2.9 | 2.1 | 94.4 |
| 20 | Eli Manning, NYG | L 24-17 vs DAL in Wk 1 | 5.1 | 0.0 | -2.7 | 0.3 | 2.7 | 37 | 3.5 | 0.4 | 53.2 |
| RK | PLAYER | RESULT | PASS EPA | RUN EPA | SACK EPA | PEN EPA | TOTAL EPA | ACT PLAYS | QB PAR | QB PAA | TOTAL QBR |
| 21 | Jay Cutler, CHI | W 41-21 vs IND in Wk 1 | 4.7 | 0.0 | -1.2 | 1.0 | 4.5 | 44 | 5.3 | 1.6 | 62.0 |
| 22 | Jake Locker, TEN | L 34-13 vs NE in Wk 1 | 3.7 | 0.8 | -1.9 | 0.5 | 3.1 | 39 | 4.4 | 1.1 | 59.7 |
| 23 | Cam Newton, CAR | L 16-10 @ TB in Wk 1 | 3.2 | -1.6 | -1.0 | -0.0 | 0.6 | 44 | 1.5 | -2.1 | 34.5 |
| 24 | Josh Freeman, TB | W 16-10 vs CAR in Wk 1 | 2.8 | 0.5 | -1.3 | 0.9 | 2.9 | 34 | 4.1 | 1.3 | 62.9 |
| 25 | Drew Brees, NO | L 40-32 vs WSH in Wk 1 | 2.2 | 0.0 | -0.9 | 0.0 | 1.3 | 62 | 3.0 | -2.2 | 38.7 |
| 26 | Michael Vick, PHI | W 17-16 @ CLE in Wk 1 | 0.5 | -0.0 | -1.6 | -0.3 | -1.5 | 70 | 0.2 | -5.6 | 25.8 |
| 27 | Andrew Luck, IND | L 41-21 @ CHI in Wk 1 | 0.4 | 0.8 | -0.9 | 0.8 | 1.1 | 53 | 2.7 | -1.7 | 39.2 |
| 28 | John Skelton, ARI | W 20-16 vs SEA in Wk 1 | 0.3 | -0.7 | -0.2 | 0.9 | 0.3 | 35 | 0.9 | -2.0 | 31.4 |
| 29 | Russell Wilson, SEA | L 20-16 @ ARI in Wk 1 | 0.2 | -2.0 | -3.0 | 4.1 | -0.7 | 56 | 0.6 | -4.1 | 27.5 |
| 30 | Tyrod Taylor, BAL | W 44-13 vs CIN in Wk 1 | 0.1 | 0.1 | 0.0 | 0.0 | 0.2 | 4 | 0.8 | 0.5 | 74.7 |
| RK | PLAYER | RESULT | PASS EPA | RUN EPA | SACK EPA | PEN EPA | TOTAL EPA | ACT PLAYS | QB PAR | QB PAA | TOTAL QBR |
| 31 | Andy Dalton, CIN | L 44-13 @ BAL in Wk 1 | 0.1 | -0.7 | -1.6 | 0.3 | -1.9 | 46 | -1.9 | -5.8 | 15.7 |
| 32 | Colin Kaepernick, SF | W 30-22 @ GB in Wk 1 | 0.0 | 0.7 | 0.0 | 0.0 | 0.7 | 1 | 0.7 | 0.6 | 99.9 |
| Bruce Gradkowski, CIN | L 44-13 @ BAL in Wk 1 | 0.0 | -0.1 | 0.0 | 0.0 | -0.1 | 1 | -0.5 | -0.6 | 0.2 | |
| Tim Tebow, NYJ | W 48-28 vs BUF in Wk 1 | 0.0 | -0.4 | 0.0 | -0.1 | -0.6 | 6 | -1.1 | -1.5 | 3.9 | |
| 35 | Matt Hasselbeck, TEN | L 34-13 vs NE in Wk 1 | -0.4 | 0.0 | 0.0 | 0.2 | -0.2 | 12 | -0.2 | -1.2 | 20.3 |
| 36 | Ryan Fitzpatrick, BUF | L 48-28 @ NYJ in Wk 1 | -1.4 | 0.9 | 0.0 | -0.2 | -0.7 | 37 | -0.7 | -3.7 | 20.4 |
| 37 | Ryan Tannehill, MIA | L 30-10 @ HOU in Wk 1 | -5.3 | -1.1 | -0.7 | -0.5 | -7.6 | 45 | -8.0 | -11.7 | 3.1 |
| 38 | Brandon Weeden, CLE | L 17-16 vs PHI in Wk 1 | -11.6 | -3.3 | -2.4 | 0.7 | -16.6 | 42 | -11.3 | -14.8 | 0.9 |
