2010 Regular Season NFL Leaders
| RK | PLAYER | PASS EPA | RUN EPA | SACK EPA | PENALTY EPA | TOTAL EPA | ACT PLAYS | CW AVG | TOTAL QBR |
| 1 | Tom Brady, NE | 97.0 | -1.9 | -15.7 | 2.5 | 81.9 | 606 | 0.9 | 75.8 |
| 2 | Peyton Manning, IND | 95.4 | -1.8 | -9.4 | 8.6 | 92.9 | 779 | 1.0 | 69.4 |
| 3 | Matt Ryan, ATL | 101.8 | -3.4 | -20.0 | 14.3 | 92.8 | 709 | 1.1 | 68.5 |
| 4 | Aaron Rodgers, GB | 91.4 | 15.5 | -26.3 | 0.2 | 80.8 | 627 | 1.1 | 67.9 |
| 5 | Michael Vick, PHI | 60.9 | 17.5 | -26.1 | 3.9 | 56.1 | 547 | 0.9 | 66.6 |
| 6 | Drew Brees, NO | 117.5 | -4.6 | -24.8 | 1.3 | 89.4 | 760 | 1.1 | 65.5 |
| 7 | Eli Manning, NYG | 66.1 | -1.2 | -10.3 | 2.9 | 57.5 | 654 | 0.9 | 64.2 |
| 8 | Josh Freeman, TB | 76.6 | 12.2 | -24.0 | 3.4 | 68.3 | 626 | 1.1 | 63.3 |
| 9 | Philip Rivers, SD | 92.8 | -6.4 | -22.9 | -3.0 | 60.5 | 667 | 0.9 | 62.9 |
| 10 | Ben Roethlisberger, PIT | 66.9 | 1.7 | -25.4 | -0.5 | 42.8 | 499 | 1.0 | 59.6 |
| RK | PLAYER | PASS EPA | RUN EPA | SACK EPA | PENALTY EPA | TOTAL EPA | ACT PLAYS | CW AVG | TOTAL QBR |
| 11 | Tony Romo, DAL | 29.3 | 5.2 | -4.7 | -4.1 | 25.7 | 251 | 1.3 | 58.1 |
| 12 | Matt Schaub, HOU | 71.7 | -5.4 | -22.2 | 5.6 | 49.7 | 678 | 0.9 | 57.8 |
| 13 | Joe Flacco, BAL | 83.8 | -8.6 | -28.6 | 10.3 | 56.9 | 647 | 1.1 | 57.5 |
| 14 | David Garrard, JAC | 63.1 | 11.1 | -27.9 | -1.8 | 44.5 | 510 | 1.1 | 57.3 |
| 15 | Kerry Collins, TEN | 33.5 | -5.3 | -9.9 | 3.8 | 22.1 | 342 | 0.9 | 56.0 |
| 16 | Matt Cassel, KC | 46.6 | -1.7 | -15.4 | 2.3 | 31.9 | 566 | 1.0 | 50.9 |
| 17 | Ryan Fitzpatrick, BUF | 46.5 | 2.1 | -19.5 | -1.0 | 28.2 | 551 | 1.1 | 47.8 |
| 18 | Mark Sanchez, NYJ | 54.5 | 2.4 | -23.8 | 2.2 | 35.3 | 619 | 1.2 | 47.4 |
| 19 | Kyle Orton, DEN | 42.6 | 3.9 | -23.3 | 2.8 | 26.1 | 612 | 1.0 | 46.5 |
| 20 | Colt McCoy, CLE | 21.9 | 5.5 | -16.3 | 0.8 | 11.9 | 290 | 1.0 | 46.2 |
| RK | PLAYER | PASS EPA | RUN EPA | SACK EPA | PENALTY EPA | TOTAL EPA | ACT PLAYS | CW AVG | TOTAL QBR |
| 21 | Carson Palmer, CIN | 49.4 | -8.6 | -17.0 | 6.8 | 30.7 | 720 | 1.0 | 46.2 |
| 22 | Jon Kitna, DAL | 33.5 | -5.0 | -11.4 | -1.3 | 15.8 | 409 | 0.9 | 46.1 |
| 23 | Shaun Hill, DET | 30.8 | 2.3 | -11.9 | -1.7 | 19.4 | 499 | 1.0 | 44.8 |
| 24 | Jason Campbell, OAK | 42.3 | 0.1 | -24.3 | -0.5 | 17.6 | 479 | 1.0 | 43.8 |
| 25 | Jay Cutler, CHI | 70.1 | -2.0 | -47.9 | 2.5 | 22.8 | 596 | 1.2 | 42.6 |
| 26 | Matt Hasselbeck, SEA | 37.6 | -1.5 | -19.3 | -2.3 | 14.5 | 547 | 0.8 | 42.5 |
| 27 | Chad Henne, MIA | 55.9 | -10.9 | -23.1 | -0.8 | 21.2 | 604 | 1.2 | 41.5 |
| 28 | Donovan McNabb, WSH | 42.4 | 7.2 | -30.5 | -1.6 | 17.4 | 596 | 1.1 | 41.0 |
| 29 | Sam Bradford, STL | 46.3 | -7.9 | -22.1 | 1.8 | 18.1 | 731 | 1.0 | 40.1 |
| 30 | Alex Smith, SF | 27.3 | -5.1 | -12.5 | 0.2 | 9.9 | 426 | 1.0 | 39.9 |
| RK | PLAYER | PASS EPA | RUN EPA | SACK EPA | PENALTY EPA | TOTAL EPA | ACT PLAYS | CW AVG | TOTAL QBR |
| 31 | Derek Anderson, ARI | 21.6 | -3.4 | -17.8 | 3.3 | 3.7 | 387 | 1.0 | 35.9 |
| 32 | Brett Favre, MIN | 14.3 | -9.6 | -17.9 | -0.1 | -13.2 | 458 | 1.1 | 26.0 |
| 33 | Jimmy Clausen, CAR | -2.4 | -10.3 | -19.5 | -0.5 | -32.7 | 396 | 0.8 | 11.9 |
