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INDIANAPOLIS -- Blaine Gabbert saw the play perfectly Sunday in Indianapolis.

The hard part was putting the ball in the right spot.

Jacksonville's second-year quarterback threw a perfect strike to Cecil Shorts III, who sprinted to the end zone for an 80-yard score with 45 seconds to go to give the Jags a stunning 22-17 victory and beat No. 1 draft pick Andrew Luck at his own comeback game.

"I told the guys going out onto the field, `We're going to win. Right here, right now," Gabbert said. "We happened to get the right look for the play that was called. We just went with it."

Gabbert made sure the play worked.

To everyone, except perhaps Gabbert, it was a shocking turnabout for a team that had a franchise-low 117 total yards last week and seemed destined for a third straight loss just seconds earlier when Adam Vinatieri made a 37-yard field goal to give the Colts a 17-16 lead with 56 seconds to go.

And after relying almost exclusively on Maurice Jones-Drew to wipe out a 14-3 halftime deficit, and after completing only three passes in the final two quarters, Gabbert jogged onto the field never doubting himself or his teammates.

Instead, Gabbert made the play of the day by throwing his only scoring pass of the game, picking up his first fourth-quarter comeback as a pro and giving coach Mike Mularkey his first win with the Jags (1-2).

"God's play, 32-power," Jones-Drew said. "When you don't get a (defensive) touch, you've got to make the other team pay."

It looked simple.

Shorts ran a crossing route right in front of one of his teammates, and when Colts backup safety Sergio Brown stepped up to cover the speedster, Gabbert pounced on the mistake.

He hit Shorts in stride and without a single Colts defender behind him. All Shorts had to do was sprint to the end zone and avoid a potential game-saving tackle by Cassius Vaughn as he dived in for the touchdown.

A replay review confirmed that Shorts' leaping lunge allowed the ball to cross the goal line before his knee came down at about the Colts 1.

The Lucas Oil Stadium crowd, which was poised to celebrate Luck's second straight comeback victory, went silent.

"This one's going to sit in the pit of their stomachs for quite some time," Colts coach Chuck Pagano said, referring to his players. "Obviously, we're going to have to get over it and move on and get better from here."

There was plenty of blame to go around.

Indy (1-2) struggled offensively for most of the second half. Luck had his troubles, too, throwing an interception right into the hands of Jags linebacker Paul Posluszny and was nearly picked off by Posluszny again in the fourth quarter.

The defense blew a 14-3 halftime lead, giving up a 59-yard TD run to Jones-Drew on Jacksonville's first offensive play of the second half, and it couldn't preserve the 16-14 lead for a single play.

Even Vinatieri, the best clutch kicker in NFL history, wound up missing a potential go-ahead 36-yard field goal to the left with 4:40 to go.

The combination forced Luck to rally the Colts twice, falling short the second time when Aaron Ross broke up a 26-yard pass intended for Reggie Wayne in the end zone on the game's final play.

Luck finished 22 of 46 for 313 yards with two scores and left with plenty to ponder heading into the Colts' bye week.

"I point the finger at myself, some bad decisions," he said. "I think the big finger should be pointed at me. I'm sure everybody feels like they have something to clean up."

The Colts were cruising at halftime after rookie T.Y. Hilton and running back Mewelde Moore each caught TD passes from Luck.

But Jones-Drew changed that with the long run to open the second half. He finished with 28 carries for 177 yards and scored his first rushing TD of the season to break Fred Taylor's franchise record with No. 63. It was his eighth time in 13 games against the Colts that Jones-Drew has topped the 100-yard mark.

Josh Scobee finally gave Jacksonville the lead on a 26-yard field goal with 11:02 to play.

That's when things got crazy.

Vinatieri followed his miss by barely slipping the 37-yarder inside the left upright, and on the next offensive play, Shorts beat Brown and Gabbert found him for the come-from-behind win.

"Great throw, great catch, great call by (offensive coordinator) Bob Bratkowski," Mularkey said. "You talk about timing -- that thing just whizzed around the ear of the defender. For Cecil to catch it through his hands and in stride and outrun everybody -- great play."

Game notes

The Jaguars played without three starters -- left guard Eben Britton (ankle), right tackle Cam Bradfield (ankle), linebacker Daryl Smith (groin) -- and lost two running back Montell Owens and receiver Laurent Robinson with concussions during the game. Cornerback Derek Cox did return to the field Sunday but spent much of the fourth quarter riding a stationary back. ... Indy's Edgerrin James became the fifth player inducted into the Colts' Ring of Honor at halftime. ... The Colts lost center Samson Satele for the second straight game with a knee injury and receiver Austin Collie with a right knee injury that will require an MRI.