Johnson finished off a career day by turning a screen pass from Matt Schaub into a 48-yard sprint for the winning touchdown as the Texans rallied to beat Jacksonville 43-37.
"All the good teams find a way to win, no matter if it's ugly, pretty or whatever," Johnson said. "In the win column, it either says 'W' or 'L.' They don't ask how you got it done."
Schaub threw a career-high five touchdown passes, completed a franchise-record 43 passes and finished with 527 yards in the air, second most in NFL history. Warren Moon also threw for 527 yards for the Houston Oilers in December 1990 in Kansas City. Norm Van Brocklin holds the record with 554 for the Rams in 1951.
Johnson caught 14 passes for 273 yards, both career highs; the yardage was a team record. He turned 31 in July, but has been saying for weeks that he's feeling as fit and healthy as he ever has.
"Maybe you guys will believe me after that," Johnson told reporters after the game.
He seemed to be open all day and he was somehow uncovered again when Schaub flipped him the short pass for the decisive score.
"When I caught the ball, and I saw how open I was, I was looking around like, 'Where are the defenders at?' " Johnson said. "I took off running, I kept looking. I thought the cornerback would come from the outside, but he wasn't there. It was just the safety, so I was just saying to myself, 'I can't let him tackle me.' "
It almost didn't come to that. Houston trailed 34-20 with 12 minutes left, but Schaub completed 16 consecutive throws to launch the comeback.
"Something we can look back on as we move through this," Schaub said, "because there are going to be games like that, that are not always going to be a two- or three-score lead in the fourth quarter, where you're trying to run the clock out."
The Texans (9-1) won an overtime game for the first time at Reliant Stadium and improved to 2-7 in overtime in their history. The Jaguars (1-9) have lost three road games in overtime this year.
"I told them afterwards, we didn't come here for a tie," Jacksonville coach Mike Mularkey said. "We had some chances. We just did not make some of the plays that we haven't made throughout the year."
Henne threw a career-high four touchdown passes in relief of injured Blaine Gabbert, and Blackmon made seven catches for 236 yards. It was the second time in NFL history opposing players each had more than 200 yards receiving in the same game; the first was in 2007, when Kevin Curtis had 211 yards for the Eagles and Roy Williams had 204 yards for the Lions in a 56-21 Eagles win.
The Jaguars looked like they were on their way to one of the biggest upsets of the season when Henne hooked up with Blackmon for a stunning 81-yard touchdown with 12:33 left in regulation to put Jacksonville up 34-20.
Schaub then threw two touchdown passes to tight end Garrett Graham in the final 5:39 to force overtime.
Henne threw incomplete on fourth-and-10 from the Houston 47, and the Texans regained possession with 2:30 left in OT. Schaub saw the perfect defense for a receiver screen pass to Johnson, who took the pass and sprinted untouched down the right sideline to end it.
"We got what we wanted," Schaub said, "and 'Dre did the rest."
Johnson surpassed his own single-game records for receptions and yards receiving. Kubiak thinks those records may stand for a while.
"I don't know if that one will ever be touched," Kubiak said. "That was special from the Texans standpoint."
Gabbert left in the first quarter with a bruised right elbow. Mularkey said last week that he was sticking with Gabbert as his starter, but he may have to go with Henne now. He didn't have an update on Gabbert's injury after the game and will decide later whether to start Gabbert next week.
With Henne guiding the offense, Jacksonville had 238 yards by halftime.
"You've just got to always be prepared and ready to go in," Henne said. "I've been preparing these last couple weeks like I've got to be the starter, and any time he (Gabbert) goes down, just jump in and hopefully not lose a step."
Jaguars RB Maurice Jones-Drew missed his fourth straight game with a strained left foot. ... LB Paul Posluszny took four stitches on his forehead after being injured in overtime. ... The Texans finished with a franchise record 640 total yards. ... Texans backup running back Ben Tate sat out for the third straight game with a hamstring injury. ... Johnson went over 100 yards receiving for the 41st time. ... Texans CB Johnathan Joseph left in the second half with a hamstring injury.
Kirk Cousins showed solid accuracy and patience in Sunday's win. He also was helped by Dominique Rodgers-Cromartie, who dropped a potential pick-six.
"It's definitely a rivalry," according to Brandon Marshall, but much more than city bragging rights will be on the line when the Jets and Giants meet.
ESPN Cardinals reporter Josh Weinfuss believes that while the Cardinals are preparing to have Chris Johnson back in time for the Super Bowl, the team's chances of making the Super Bowl without him are slim.
David Johnson leads all rookie running backs and receivers with eight total touchdowns -- four rushing, three receiving and one return touchdown.
The Patriots and Rob Gronkowski's family released a joint statement saying that the injured tight end has no timetable for a return.
Colts reporter Mike Wells says quarterback Matt Hasselbeck signed with Indianapolis in 2013 with the goal of winning a Super Bowl.