The Bears (4-2) snapped a two-game slide following a 3-0 start. New York is 0-6 for the first time since the 1976 team dropped its first nine, a stunning turn for a franchise that won the Super Bowl two years ago.
"We see things each and every week that tell us we cannot just be good, we can be very good," Bears coach Marc Trestman said. "But we also know there's a lot of work ahead."
The Giants came in clinging to the idea that they could claw their way back into the NFC East race because every team in the division has a losing record. It's hard to see that happening, the way they're playing.
"We're all sick of it," coach Tom Coughlin said. "We're all sick of losing, but we put ourselves in this position. There is only one way to get out of it."
Cutler and Marshall were in tune early on, connecting for two touchdowns, and Jennings returned an interception 48 yards for a score as Chicago built a 24-14 halftime lead.
The Bears were up by 13 when New York's Brandon Jacobs ran it in from the 1 in the closing seconds of the third after Jennings got called for interference against Hakeem Nicks near the goal line. That cut it to 27-21, but Jennings made up for it in a big way when he picked off an overthrown pass by Manning intended for tight end Brandon Myers at the 10 with 1:54 left in the game.
Cutler was 24 of 36 for 262 yards after throwing for 358 against New Orleans last week. Marshall played a huge role in this one after venting over a lack of catches against the Saints, finishing with nine receptions for 87 yards. Martellus Bennett had 68 yards on six catches against his former team, while Alshon Jeffery had just one reception after going off for a franchise-record 218 yards in the previous game.
"We won the game, but we kind of leave a little bit unsatisfied because I think offensively we could have exploded for a little bit more," Cutler said.
Robbie Gould kicked two field goals, including a 52-yarder in the third quarter that gave him 12 straight conversions from 50 or longer, and the Bears eased at least a few nerves, even if this win came against one of the NFL's four winless teams.
Manning, the owner of two championship rings, completed 14 of 26 passes for 239 yards and a touchdown, but he ran his league-leading total to 15 interceptions while matching last season's number. He had passes picked off on the first two possessions, with Jennings' 48-yard TD coming on the second one.
"I feel bad for my teammates. I feel bad for my coaches and everybody, fighting every day, and I'm fighting, too," Manning said. "I am trying to get a win for these guys."
It's not easy when he keeps throwing it to the other team. But the Giants aren't about to go away from him.
"You're not going to go back to not throwing the football. That's not something that's going to happen," Coughlin said. "He's been too successful for so many years throwing the ball."
Cutler threw for 179 yards in the first two quarters, Marshall had 65 and the Bears racked up 227 yards in the opening half. The Giants (212 yards) moved the ball in the early going but had trouble hanging onto the ball again -- no surprise there.
After all, they came in leading the league with 20 turnovers. The Bears, who had 14 takeaways when the night began, quickly added to that total.
Zack Bowman, starting for Charles Tillman (right knee injury), picked off a pass intended for Randle on the game's third play from scrimmage at the 36 and returned it to the New York 12. The Bears came away empty-handed on an incomplete pass from Cutler to Marshall on fourth-and-2 at the 4, but they quickly grabbed the lead on the Giants' next possession. Jennings got an easy interception on what looked like a miscommunication between Manning and Randle, returning it 48 yards for his second touchdown this season.
The Giants then drove 80 yards to tie it at 7, with Jacobs dragging Corey Wootton and Jennings as he plowed in on a 4-yard run. Marshall, wearing lime green shoes in honor of mental health awareness week, put the Bears back on top with a 10-yard TD catch in the opening minute of the second quarter to finish an 86-yard drive.
New York quickly tied it when Randle stayed inbounds along the sideline on a 37-yard TD catch, but Chicago immediately answered with an 80-yard scoring drive, with Cutler connecting with Marshall on a 3-yard pass to make it 21-14.
Gould added a 40-yarder in the closing seconds of the half to extend the lead to 10.
Devin Hester became the Bears' career leader in kickoff return yards. He has 4,643 after running back three for 73 yards. ... Trestman had no update on linebacker D.J. Williams, who left the game with a chest injury, but did say Tillman probably would have been available had they played on Sunday. ... Giants RB Da'Rel Scott suffered a hamstring injury on a 13-yard run on New York's final possession. ... Wilson and center David Baas missed the game because of neck injuries, while cornerback Corey Webster sat out his fourth in a row because of a groin problem.
Doctors treating Giants tight end Daniel Fells for MRSA are more optimistic than they were a few days ago that Fells won't lose his foot, sources close to the situation said.
The NFL has blamed an error by a clock operator, and the failure to correct it by on-field officials, for an unusual run-off of 18 seconds near the end of Monday's Steelers-Chargers game.
With starter Tyrod Taylor potentially dealing with an undisclosed injury, the Buffalo Bills signed veteran quarterback Josh Johnson on Tuesday and released veteran kicker Billy Cundiff.
The Denver Broncos are planning to be without pass-rusher DeMarcus Ware for Sunday's game against the Cleveland Browns, a source told ESPN NFL Insider Ed Werder.
DeAngelo Williams was told over the phone by NFL vice president of football operations Troy Vincent that he couldn't wear pink accessories because there are no exceptions to the uniform policy.
The Jaguars have been unable to determine when Bernard Pierce suffered a concussion in Sunday's loss to Tampa Bay, and the running back told the team he's also unsure when it happened.