The undrafted free agent threw three touchdown passes in his first NFL start and the Raiders extended Houston's franchise-record skid to eight games with a 28-23 victory on Sunday in coach Gary Kubiak's return from a mini-stroke.
Oakland coach Dennis Allen evaded the question when asked if McGloin would remain the starter when Pryor has recovered from a knee injury.
"Listen, here's what I'm going to do -- I'm going to enjoy this win, all right," Allen said. "We're going to go back and we'll evaluate. But he definitely did a very good job today."
McGloin was 18 of 32 for 197 yards. Houston's Case Keenum, also an undrafted free agent, was benched after Houston's offense stalled in the third quarter.
McGloin threw touchdown passes of 5, 16 and 26 yards to help the Raiders score their most points of the season.
"There is always more to prove and more to do," McGloin said. "I think I got off to a good start, but we will see."
Kubiak wasn't on the sidelines, instead coaching upstairs from the booth on doctor's orders two weeks after collapsing at halftime of Houston's game against Indianapolis.
He benched Keenum for Matt Schaub with Houston trailing by 11 points. Houston cut the lead with two field goals in the fourth quarter and had a chance to take the lead late. But Schaub's pass to Andre Johnson on fourth down from the 8 was broken up in the end zone.
Johnson and Schaub were yelling at each other on the field after the play and the screaming match continued on the sidelines, a clear indication of the frustration on a disappointing team that was supposed to contend for a Super Bowl.
Johnson said the argument came because he "messed up" and didn't finish the play.
"We just exchanged some words," he said. "It's just heat of the moment. Once we came in the locker room, we talked about it, left it alone so I'm not worried about that. Me and Matt have played a lot of football together."
Schaub also brushed off their disagreement.
"It's just emotions, emotions of the game, a culmination of a lot of things, but stuff we'll keep between us," Schaub said.
Kubiak replaced Keenum with Schaub after Houston's first three drives of the second half all ended in punts. Schaub was terrible early this season and hadn't played since Oct. 13, after he was benched following an injury.
Keenum threw for 170 yards with a touchdown and an interception. Schaub had 155 yards passing.
Kubiak wouldn't say who would start next week.
Houston punted on Schaub's first drive before settling for a 26-yard field goal on the second when the offense stalled after getting a first down at the 10.
A 30-yard field goal cut the lead to 28-23 with about eight minutes remaining.
Rashad Jennings, who was filling in for the injured Darren McFadden, extended Oakland's lead to 28-17 when he plowed over D.J. Swearinger and rumbled 80 yards for a touchdown with 2:26 left in the third quarter. It was the longest run of his career and he finished with 150 yards rushing.
The Raiders regained the lead when Mychal Rivera grabbed a 26-yard touchdown reception to make it 21-17 in the third quarter.
Houston tied it at 14 when Keshawn Martin let a punt bounce off the grass and his chest before scooping it up and dashing 87 yards for a touchdown about three minutes before halftime. It was the longest punt return for a score in franchise history.
Randy Bullock made his first field goal of 50 or more yards with a 51-yarder to give Houston a 17-14 lead just before halftime.
McGloin's first career touchdown came when he hit Denarius Moore on a 5-yard slant to put Oakland up 7-0.
Houston's second miscue came when Keenum threw his first career interception as he was being hit by Stacy McGee. It broke a streak of 105 pass attempts without an interception for Keenum.
The Raiders immediately took advantage of the error when McGloin connected with Rod Streater for a 16-yard touchdown on the next play to make it 14-0.
Former Presidents George H. Bush and George H.W. Bush were on the field before the game and the younger Bush did the coin flip. ... McGloin is the 17th quarterback to start for the Raiders since the start of the 2003 season. ... Oakland defensive tackle Daniel Muir and right guard Mike Brisiel both sustained knee injuries and Allen said he'll know more after they have MRIs.
Dannell Ellerbe, David Hawthorne and Damian Swann won't play Sunday, while Mark Ingram, Stephone Anthony and Hau'oli Kikaha are listed as probable.
NFL vice president of officiating Dean Blandino acknowledged Friday that the inadvertent whistle in the Bills-Patriots game blew before the catch.
Carlos Hyde will miss his fourth straight game as he continues to recover from the stress fracture in his left foot.
Seferian-Jenkins, who's dealing with a shoulder injury, has been out for eight weeks. Overall, the Bucs are pretty healthy for late November.
The Broncos' young quarterback performed admirably in his first career start, but Bill Belichick and company will throw him a few curveballs.
Greg Olsen and the rest of the Panthers were surprised to find more than 100 fans waiting at Bank of America Stadium at 1 a.m. to welcome them home.