Offensive Leaders
| QUARTERBACK RATING | RAT | |
Brett Favre | 1. Brett Favre, MIN | 112.1 |
| 2. Drew Brees, NO | 105.8 | |
| 3. Peyton Manning, IND | 102.7 | |
| 4. Aaron Rodgers, GNB | 102.6 | |
| 5. Tom Brady, NE | 100.4 | |
| Complete Leaders | ||
| RUSHING YARDS | YDS | |
Chris Johnson | 1. Chris Johnson, TEN | 1242 |
| 2. Steven Jackson, STL | 1031 | |
| 3. Adrian Peterson, MIN | 999 | |
| 4. DeAngelo Williams, CAR | 982 | |
| 5. Maurice Jones-Drew, JAC | 926 | |
| Complete Leaders | ||
| RECEIVING YARDS | YDS | |
Reggie Wayne | 1. Reggie Wayne, IND | 968 |
| 2. Randy Moss, NE | 925 | |
| 3. Andre Johnson, HOU | 878 | |
| 4. Sidney Rice, MIN | 875 | |
| 5. Wes Welker, NE | 854 | |
| Complete Leaders | ||
Defensive Leaders
| TACKLES | TACK | |
Curtis Lofton | 1. Curtis Lofton, ATL | 101 |
| 2. Patrick Willis, SF | 96 | |
| 3. London Fletcher, WAS | 90 | |
| 4. David Harris, NYJ | 88 | |
| 5. Brian Cushing, HOU | 88 | |
| Complete Leaders | ||
| SACKS | SACK | |
Elvis Dumervil | 1. Elvis Dumervil, DEN | 12 |
| 2. Jared Allen, MIN | 10.5 | |
| 3. James Harrison, PIT | 10 | |
| 4. Dwight Freeney, IND | 9.5 | |
| 5. Trent Cole, PHI | 8.5 | |
| Complete Leaders | ||
| INTERCEPTIONS | INT | |
Jairus Byrd | 1. Jairus Byrd, BUF | 8 |
| 2. Darren Sharper, NO | 7 | |
| 3. Aqib Talib, TB | 5 | |
| 4. Charles Woodson, GNB | 5 | |
| 5. Johnathan Joseph, CIN | 5 | |
| Complete Leaders | ||
Data provided by Elias Sports Bureau