Offensive Leaders
| QUARTERBACK RATING | RAT | |
Peyton Manning | 1. Peyton Manning, IND | 121.1 |
| 2. Daunte Culpepper, MIN | 110.9 | |
| 3. Drew Brees, SD | 104.8 | |
| 4. Donovan McNabb, PHI | 104.7 | |
| 5. Ben Roethlisberger, PIT | 98.1 | |
| Complete Leaders | ||
| RUSHING YARDS | YDS | |
Curtis Martin | 1. Curtis Martin, NYJ | 1697 |
| 2. Shaun Alexander, SEA | 1696 | |
| 3. Corey Dillon, NE | 1635 | |
| 4. Edgerrin James, IND | 1548 | |
| 5. Tiki Barber, NYG | 1518 | |
| Complete Leaders | ||
| RECEIVING YARDS | YDS | |
Muhsin Muhammad | 1. Muhsin Muhammad, CAR | 1405 |
| 2. Joe Horn, NO | 1399 | |
| 3. Javon Walker, GNB | 1382 | |
| 4. Torry Holt, STL | 1372 | |
| 5. Isaac Bruce, STL | 1292 | |
| Complete Leaders | ||
Defensive Leaders
| TACKLES | TACK | |
Keith Bulluck | 1. Keith Bulluck, TEN | 152 |
| 2. Donnie Edwards, SD | 150 | |
| 3. Ray Lewis, BAL | 146 | |
| 4. Zach Thomas, MIA | 145 | |
| 5. London Fletcher, BUF | 142 | |
| Complete Leaders | ||
| SACKS | SACK | |
Dwight Freeney | 1. Dwight Freeney, IND | 16 |
| 2. Bertrand Berry, ARI | 14.5 | |
| 3. Kabeer Gbaja-Biamila, GNB | 13.5 | |
| 4. Patrick Kerney, ATL | 13 | |
| 5. Simeon Rice, TB | 12 | |
| Complete Leaders | ||
| INTERCEPTIONS | INT | |
Ed Reed | 1. Ed Reed, BAL | 9 |
| 2. Tory James, CIN | 8 | |
| 3. Dunta Robinson, HOU | 6 | |
| 4. Andre Dyson, TEN | 6 | |
| 5. Nate Clements, BUF | 6 | |
| Complete Leaders | ||
Data provided by Elias Sports Bureau