Offensive Leaders
| QUARTERBACK RATING | RAT | |
Peyton Manning | 1. Peyton Manning, IND | 101 |
| 2. Damon Huard, KC | 98 | |
| 3. Drew Brees, NO | 96.2 | |
| 4. Donovan McNabb, PHI | 95.5 | |
| 5. Tony Romo, DAL | 95.1 | |
| Complete Leaders | ||
| RUSHING YARDS | YDS | |
LaDainian Tomlinson | 1. LaDainian Tomlinson, SD | 1815 |
| 2. Larry Johnson, KC | 1789 | |
| 3. Frank Gore, SF | 1695 | |
| 4. Tiki Barber, NYG | 1662 | |
| 5. Steven Jackson, STL | 1528 | |
| Complete Leaders | ||
| RECEIVING YARDS | YDS | |
Chad Ochocinco | 1. Chad Ochocinco, CIN | 1369 |
| 2. Marvin Harrison, IND | 1366 | |
| 3. Roy E. Williams, DET | 1310 | |
| 4. Reggie Wayne, IND | 1310 | |
| 5. Donald Driver, GNB | 1295 | |
| Complete Leaders | ||
Defensive Leaders
| TACKLES | TACK | |
Zach Thomas | 1. Zach Thomas, MIA | 165 |
| 2. DeMeco Ryans, HOU | 156 | |
| 3. London Fletcher, BUF | 146 | |
| 4. Keith Bulluck, TEN | 144 | |
| 5. Cato June, IND | 143 | |
| Complete Leaders | ||
| SACKS | SACK | |
Shawne Merriman | 1. Shawne Merriman, SD | 17 |
| 2. Aaron Kampman, GNB | 15.5 | |
| 3. Aaron Schobel, BUF | 14 | |
| 4. Jason Taylor, MIA | 13.5 | |
| 5. Leonard Little, STL | 13 | |
| Complete Leaders | ||
| INTERCEPTIONS | INT | |
Champ Bailey | 1. Champ Bailey, DEN | 10 |
| 2. Asante Samuel, NE | 10 | |
| 3. Rashean Mathis, JAC | 8 | |
| 4. Walt Harris, SF | 8 | |
| 5. Charles Woodson, GNB | 8 | |
| Complete Leaders | ||
Data provided by Elias Sports Bureau
