Offensive Leaders
| QUARTERBACK RATING | RAT | |
Tom Brady | 1. Tom Brady, NE | 117.2 |
| 2. Ben Roethlisberger, PIT | 104.1 | |
| 3. David Garrard, JAC | 102.2 | |
| 4. Peyton Manning, IND | 98 | |
| 5. Tony Romo, DAL | 97.4 | |
| Complete Leaders | ||
| RUSHING YARDS | YDS | |
LaDainian Tomlinson | 1. LaDainian Tomlinson, SD | 1474 |
| 2. Adrian Peterson, MIN | 1341 | |
| 3. Brian Westbrook, PHI | 1333 | |
| 4. Willie Parker, PIT | 1316 | |
| 5. Jamal Lewis, CLE | 1304 | |
| Complete Leaders | ||
| RECEIVING YARDS | YDS | |
Reggie Wayne | 1. Reggie Wayne, IND | 1510 |
| 2. Randy Moss, NE | 1493 | |
| 3. Chad Ochocinco, CIN | 1440 | |
| 4. Larry Fitzgerald, ARI | 1409 | |
| 5. Terrell Owens, DAL | 1355 | |
| Complete Leaders | ||
Defensive Leaders
| TACKLES | TACK | |
Patrick Willis | 1. Patrick Willis, SF | 174 |
| 2. D.J. Williams, DEN | 141 | |
| 3. Jon Beason, CAR | 140 | |
| 4. Ernie Sims, DET | 134 | |
| 5. Nick Barnett, GNB | 131 | |
| Complete Leaders | ||
| SACKS | SACK | |
Jared Allen | 1. Jared Allen, KC | 15.5 |
| 2. Patrick Kerney, SEA | 14.5 | |
| 3. DeMarcus Ware, DAL | 14 | |
| 4. Mario Williams, HOU | 14 | |
| 5. Osi Umenyiora, NYG | 13 | |
| Complete Leaders | ||
| INTERCEPTIONS | INT | |
Antonio Cromartie | 1. Antonio Cromartie, SD | 10 |
| 2. Oshiomogho Atogwe, STL | 8 | |
| 3. Marcus Trufant, SEA | 7 | |
| 4. Ed Reed, BAL | 7 | |
| 5. Thomas Howard, OAK | 6 | |
| Complete Leaders | ||
Data provided by Elias Sports Bureau
