Offensive Leaders
| QUARTERBACK RATING | RAT | |
Philip Rivers | 1. Philip Rivers, SD | 105.5 |
| 2. Chad Pennington, MIA | 97.4 | |
| 3. Kurt Warner, ARI | 96.9 | |
| 4. Drew Brees, NO | 96.2 | |
| 5. Peyton Manning, IND | 95 | |
| Complete Leaders | ||
| RUSHING YARDS | YDS | |
Adrian Peterson | 1. Adrian Peterson, MIN | 1760 |
| 2. Michael Turner, ATL | 1699 | |
| 3. DeAngelo Williams, CAR | 1515 | |
| 4. Clinton Portis, WAS | 1487 | |
| 5. Thomas Jones, NYJ | 1312 | |
| Complete Leaders | ||
| RECEIVING YARDS | YDS | |
Andre Johnson | 1. Andre Johnson, HOU | 1575 |
| 2. Larry Fitzgerald, ARI | 1431 | |
| 3. Steve Smith, CAR | 1421 | |
| 4. Roddy White, ATL | 1382 | |
| 5. Calvin Johnson, DET | 1331 | |
| Complete Leaders | ||
Defensive Leaders
| TACKLES | TACK | |
D'Qwell Jackson | 1. D'Qwell Jackson, CLE | 154 |
| 2. Patrick Willis, SF | 141 | |
| 3. Jon Beason, CAR | 138 | |
| 4. Barrett Ruud, TB | 137 | |
| 5. Kirk Morrison, OAK | 135 | |
| Complete Leaders | ||
| SACKS | SACK | |
DeMarcus Ware | 1. DeMarcus Ware, DAL | 20 |
| 2. Joey Porter, MIA | 17.5 | |
| 3. John Abraham, ATL | 16.5 | |
| 4. James Harrison, PIT | 16 | |
| 5. Jared Allen, MIN | 14.5 | |
| Complete Leaders | ||
| INTERCEPTIONS | INT | |
Ed Reed | 1. Ed Reed, BAL | 9 |
| 2. Nick Collins, GNB | 7 | |
| 3. Michael Griffin, TEN | 7 | |
| 4. Charles Woodson, GNB | 7 | |
| 5. Troy Polamalu, PIT | 7 | |
| Complete Leaders | ||
Data provided by Elias Sports Bureau