Rushing Yards Leaders - All Players
| RK | PLAYER | TEAM | ATT | YDS | YDS/A | LONG | 20+ | TD | YDS/G | FUM | 1DN |
| 41 | Pierre Thomas, RB | NO | 110 | 562 | 5.1 | 33 | 2 | 5 | 35.1 | 1 | 28 |
| 42 | C.J. Spiller, RB | BUF | 107 | 561 | 5.2 | 38 | 7 | 4 | 35.1 | 2 | 26 |
| 43 | Ryan Grant, RB | GB | 134 | 559 | 4.2 | 47 | 2 | 2 | 37.3 | 1 | 27 |
| 44 | Toby Gerhart, RB | MIN | 109 | 531 | 4.9 | 67 | 3 | 1 | 33.2 | 1 | 24 |
| 45 | Dexter McCluster, WR | KC | 114 | 516 | 4.5 | 32 | 4 | 1 | 32.3 | 1 | 28 |
| 46 | Mike Tolbert, RB | SD | 121 | 490 | 4.1 | 40 | 3 | 8 | 32.7 | 1 | 25 |
| 47 | Isaac Redman, RB | PIT | 110 | 479 | 4.4 | 27 | 3 | 3 | 29.9 | 2 | 29 |
| 48 | Thomas Jones, RB | KC | 153 | 478 | 3.1 | 26 | 3 | 0 | 29.9 | 0 | 19 |
| 49 | Mark Ingram, RB | NO | 122 | 474 | 3.9 | 35 | 2 | 5 | 47.4 | 1 | 30 |
| 50 | Kendall Hunter, RB | SF | 112 | 473 | 4.2 | 44 | 3 | 2 | 29.6 | 0 | 21 |
| RK | PLAYER | TEAM | ATT | YDS | YDS/A | LONG | 20+ | TD | YDS/G | FUM | 1DN |
| 51 | Ricky Williams, RB | BAL | 108 | 444 | 4.1 | 28 | 3 | 2 | 27.8 | 2 | 20 |
| 52 | Stevan Ridley, RB | NE | 87 | 441 | 5.1 | 33 | 5 | 1 | 27.6 | 1 | 18 |
| 53 | Joseph Addai, RB | IND | 118 | 433 | 3.7 | 16 | 0 | 1 | 36.1 | 1 | 16 |
| 54 | Marion Barber, RB | CHI | 114 | 422 | 3.7 | 29 | 2 | 6 | 38.4 | 1 | 26 |
| 55 | Lance Ball, RB | DEN | 96 | 402 | 4.2 | 34 | 2 | 1 | 25.1 | 1 | 25 |
| 56 | Jahvid Best, RB | DET | 84 | 390 | 4.6 | 88 | 2 | 2 | 65.0 | 0 | 15 |
| 57 | Bernard Scott, RB | CIN | 112 | 380 | 3.4 | 25 | 1 | 3 | 23.8 | 0 | 20 |
| 58 | Delone Carter, RB | IND | 101 | 377 | 3.7 | 42 | 2 | 2 | 23.6 | 3 | 19 |
| 59 | Chris Ivory, RB | NO | 79 | 374 | 4.7 | 35 | 2 | 1 | 62.3 | 0 | 21 |
| 60 | Cadillac Williams, RB | STL | 87 | 361 | 4.1 | 23 | 1 | 1 | 32.8 | 0 | 19 |
| RK | PLAYER | TEAM | ATT | YDS | YDS/A | LONG | 20+ | TD | YDS/G | FUM | 1DN |
| 61 | Kevin Smith, RB | DET | 72 | 356 | 4.9 | 43 | 2 | 4 | 50.9 | 0 | 16 |
| 62 | Danny Woodhead, RB | NE | 77 | 351 | 4.6 | 12 | 0 | 1 | 23.4 | 0 | 18 |
| 63 | Percy Harvin, WR | MIN | 52 | 345 | 6.6 | 39 | 5 | 2 | 21.6 | 0 | 15 |
| 64 | Chris Ogbonnaya, RB | CLE/HOU | 76 | 340 | 4.5 | 40 | 3 | 1 | 26.2 | 2 | 13 |
| 65 | Kahlil Bell, RB | CHI | 79 | 337 | 4.3 | 26 | 2 | 0 | 25.9 | 2 | 13 |
| 66 | Evan Royster, RB | WSH | 56 | 328 | 5.9 | 28 | 2 | 0 | 54.7 | 0 | 17 |
| 67 | Tim Hightower, RB | WSH | 84 | 321 | 3.8 | 22 | 2 | 1 | 64.2 | 0 | 13 |
| 68 | Maurice Morris, RB | DET | 80 | 316 | 4.0 | 31 | 1 | 1 | 19.8 | 1 | 12 |
| 69 | LaDainian Tomlinson, RB | NYJ | 75 | 280 | 3.7 | 20 | 1 | 1 | 20.0 | 0 | 15 |
| 70 | Montario Hardesty, RB | CLE | 88 | 266 | 3.0 | 19 | 0 | 0 | 26.6 | 1 | 6 |
| RK | PLAYER | TEAM | ATT | YDS | YDS/A | LONG | 20+ | TD | YDS/G | FUM | 1DN |
| 71 | Aaron Rodgers, QB | GB | 60 | 257 | 4.3 | 25 | 1 | 3 | 17.1 | 0 | 18 |
| 72 | Leon Washington, RB | SEA | 53 | 248 | 4.7 | 48 | 3 | 1 | 15.5 | 0 | 8 |
| 73 | Josh Freeman, QB | TB | 55 | 238 | 4.3 | 25 | 1 | 4 | 15.9 | 3 | 25 |
| 74 | Christian Ponder, QB | MIN | 28 | 219 | 7.8 | 28 | 1 | 0 | 19.9 | 1 | 13 |
| 75 | Ryan Fitzpatrick, QB | BUF | 56 | 215 | 3.8 | 18 | 0 | 0 | 13.4 | 5 | 18 |
| 76 | Colt McCoy, QB | CLE | 61 | 212 | 3.5 | 20 | 1 | 0 | 16.3 | 6 | 17 |
| 77 | Earnest Graham, RB | TB | 37 | 206 | 5.6 | 34 | 2 | 0 | 29.4 | 1 | 6 |
| 78 | Jacquizz Rodgers, RB | ATL | 57 | 205 | 3.6 | 13 | 0 | 1 | 12.8 | 1 | 15 |
| 79 | Ryan Torain, RB | WSH | 59 | 200 | 3.4 | 39 | 2 | 1 | 25.0 | 1 | 5 |
| 80 | Keiland Williams, RB | DET | 58 | 195 | 3.4 | 18 | 0 | 2 | 13.0 | 2 | 10 |
Data provided by Elias Sports Bureau
