Rushing Yards Leaders - All Players
| RK | PLAYER | TEAM | ATT | YDS | YDS/A | LONG | 20+ | TD | YDS/G | FUM | 1DN |
| 1 | Willie Parker, RB | PIT | 70 | 246 | 3.5 | 27 | 1 | 2 | 82.0 | 1 | 12 |
| 2 | Edgerrin James, RB | ARI | 61 | 236 | 3.9 | 22 | 1 | 1 | 59.0 | 0 | 12 |
| 3 | Willis McGahee, RB | BAL | 39 | 154 | 3.9 | 48 | 1 | 2 | 51.3 | 0 | 7 |
| 4 | Tim Hightower, RB | ARI | 35 | 132 | 3.8 | 17 | 0 | 1 | 33.0 | 0 | 7 |
| 5 | Darren Sproles, RB | SD | 33 | 120 | 3.6 | 22 | 1 | 2 | 60.0 | 0 | 7 |
| 6 | Brian Westbrook, RB | PHI | 50 | 119 | 2.4 | 14 | 0 | 0 | 39.7 | 0 | 5 |
| 7 | Brandon Jacobs, RB | NYG | 19 | 92 | 4.8 | 24 | 1 | 0 | 92.0 | 0 | 5 |
| 8 | Le'Ron McClain, FB | BAL | 32 | 90 | 2.8 | 11 | 0 | 1 | 30.0 | 1 | 3 |
| 9 | Adrian Peterson, RB | MIN | 20 | 83 | 4.2 | 40 | 1 | 2 | 83.0 | 0 | 2 |
| 10 | Chris Johnson, RB | TEN | 11 | 72 | 6.5 | 32 | 1 | 1 | 72.0 | 0 | 2 |
| RK | PLAYER | TEAM | ATT | YDS | YDS/A | LONG | 20+ | TD | YDS/G | FUM | 1DN |
| 11 | DeAngelo Williams, RB | CAR | 12 | 63 | 5.3 | 31 | 1 | 0 | 63.0 | 0 | 3 |
| 12 | Correll Buckhalter, RB | PHI | 11 | 55 | 5.0 | 27 | 1 | 0 | 18.3 | 0 | 3 |
| 13 | Chester Taylor, RB | MIN | 12 | 48 | 4.0 | 11 | 0 | 0 | 48.0 | 0 | 2 |
| 14 | Donovan McNabb, QB | PHI | 7 | 47 | 6.7 | 21 | 1 | 1 | 15.7 | 0 | 3 |
| 15 | Derrick Ward, RB | NYG | 12 | 46 | 3.8 | 14 | 0 | 0 | 46.0 | 0 | 2 |
| 16 | LenDale White, RB | TEN | 15 | 45 | 3.0 | 12 | 0 | 0 | 45.0 | 1 | 2 |
| 17 | Joseph Addai, RB | IND | 16 | 44 | 2.8 | 11 | 0 | 1 | 44.0 | 0 | 3 |
| 18 | Michael Turner, RB | ATL | 18 | 42 | 2.3 | 13 | 0 | 1 | 42.0 | 0 | 4 |
| 19 | LaDainian Tomlinson, RB | SD | 5 | 25 | 5.0 | 13 | 0 | 1 | 25.0 | 0 | 3 |
| Mewelde Moore, RB | PIT | 5 | 25 | 5.0 | 6 | 0 | 0 | 8.3 | 0 | 1 | |
| RK | PLAYER | TEAM | ATT | YDS | YDS/A | LONG | 20+ | TD | YDS/G | FUM | 1DN |
| 21 | Michael Bennett, RB | SD | 4 | 24 | 6.0 | 14 | 0 | 0 | 12.0 | 0 | 1 |
| 22 | Ronnie Brown, RB | MIA | 12 | 19 | 1.6 | 6 | 0 | 0 | 19.0 | 0 | 0 |
| 23 | Ricky Williams, RB | MIA | 4 | 17 | 4.3 | 7 | 0 | 0 | 17.0 | 0 | 2 |
| Tarvaris Jackson, QB | MIN | 2 | 17 | 8.5 | 17 | 0 | 0 | 17.0 | 0 | 1 | |
| 25 | Mark Clayton, WR | BAL | 1 | 16 | 16.0 | 16 | 0 | 0 | 5.3 | 0 | 1 |
| 26 | Lousaka Polite, RB | MIA | 3 | 15 | 5.0 | 11 | 0 | 0 | 15.0 | 0 | 3 |
| 27 | Philip Rivers, QB | SD | 2 | 13 | 6.5 | 12 | 0 | 0 | 6.5 | 0 | 1 |
| 28 | Jonathan Stewart, RB | CAR | 3 | 12 | 4.0 | 9 | 0 | 1 | 12.0 | 0 | 1 |
| Dominic Rhodes, RB | IND | 4 | 12 | 3.0 | 5 | 0 | 0 | 12.0 | 0 | 1 | |
| Jerious Norwood, RB | ATL | 2 | 12 | 6.0 | 8 | 0 | 0 | 12.0 | 0 | 1 | |
| RK | PLAYER | TEAM | ATT | YDS | YDS/A | LONG | 20+ | TD | YDS/G | FUM | 1DN |
| 31 | Dallas Clark, TE | IND | 1 | 9 | 9.0 | 9 | 0 | 0 | 9.0 | 0 | 1 |
| 32 | Santonio Holmes, WR | PIT | 2 | 7 | 3.5 | 4 | 0 | 0 | 2.3 | 0 | 1 |
| 33 | Matt Ryan, QB | ATL | 4 | 6 | 1.5 | 2 | 0 | 0 | 6.0 | 1 | 1 |
| 34 | Joe Flacco, QB | BAL | 12 | 5 | 0.4 | 5 | 0 | 1 | 1.7 | 0 | 4 |
| Lorenzo Neal, FB | BAL | 2 | 5 | 2.5 | 4 | 0 | 0 | 1.7 | 0 | 1 | |
| J.J. Arrington, RB | ARI | 6 | 5 | 0.8 | 9 | 0 | 0 | 1.3 | 0 | 1 | |
| 37 | Gary Russell, RB | PIT | 6 | 2 | 0.3 | 3 | 0 | 2 | 0.7 | 0 | 3 |
| DeSean Jackson, WR | PHI | 1 | 2 | 2.0 | 2 | 0 | 0 | 0.7 | 0 | 0 | |
| Ray Rice, RB | BAL | 1 | 2 | 2.0 | 2 | 0 | 0 | 1.0 | 0 | 0 | |
| Troy Smith, QB | BAL | 1 | 2 | 2.0 | 2 | 0 | 0 | 2.0 | 0 | 0 |
Data provided by Elias Sports Bureau
