DENVER -- Kansas City Chiefs running back Jamaal Charles and safety Eric Berry both suffered ankle injuries in the first half of Sunday's game against the Denver Broncos, and neither star player will return.
Charles was stopped on a run up the middle early in the first quarter and then hobbled to the bench. He was examined by the Chiefs medical staff as Knile Davis replaced him in the backfield.
Kansas City was trying to get Charles more involved in the offense this week after giving him just seven carries against Tennessee. Charles rushed for 1,287 yards a season ago, which was third-most in the NFL.
Berry was looked at on the sideline by the medical staff late in the second quarter, before taking the tape off his ankle and heading toward the locker room. He was replaced by Ron Parker.
The Chiefs lost three starters for the season with injuries in last week's game. Linebacker Derrick Johnson and defensive end Mike DeVito each ruptured an Achilles tendon while offensive lineman Jeff Allen injured his elbow.
The Associated Press contributed to this report.