Colts coach Chuck Pagano said Monday that the Pro Bowl receiver is day-to-day.
"Touched my knee [Sunday] and it was really numb," said Hilton, who finished with seven catches for 88 yards. "I felt a lot of swelling. It blew up on me real fast. Just hurting, sore to the touch.
"I should be all right. I feel better, actually a lot better. Going on, like, my fourth treatment right now. Haven't felt that [before], so it was really scary."
Colts owner Jim Irsay said after the game that he felt like Hilton could "miss some time." Indianapolis' next game is next Monday night against the New York Jets.
"Monday night speaks for itself," Hilton said. "Everybody is watching Monday night, so it means a lot, especially going against a great Jets defense. It's one I really don't want to miss."
Second-year receiver Donte Moncrief would likely start opposite of Andre Johnson if Hilton doesn't play. Not having Hilton would put more pressure on rookie Phillip Dorsett, who would become the team's third receiver. Dorsett fumbled two punts -- losing one -- and had two receptions for 45 yards against the Bills.
"We've seen enough in OTAs and offseason programs and training camp," Pagano said. "He has to trust himself, play with confidence. Go out and make plays. He's more than capable."