Brown plans to have surgery this week. He wore a brace over his entire right leg in the locker room after the regular-season finale and was using crutches.
"I give everything to this game, man. I give everything -- my heart, my soul, my being -- to this game, to this organization, to this team, and I find a lot of joy being out there with my guys every Sunday," Brown said. "Being sidelined for any amount of time is devastating for me."
Houston's sideline emptied as teammates went to see off Brown, who was helped onto a cart that took him to the locker room. Brown had tears in his eyes as he left the field.
"This is the most serious injury I have had in my pro career," Brown said. "With all of those thoughts flowing, it was emotional for me."
Brown, a two-time Pro Bowler, has been the Texans' left tackle since the organization drafted him in 2008. He is the longest-tenured player on the team and one of only a handful of Texans starters who were also starters in 2012, the most recent year the Texans made the playoffs.
Brown has played in 119 games for the Texans and has started all of them. He was selected as a first alternate to the Pro Bowl this season.