Strief went down on New Orleans' first drive of the second half and needed help getting to the sideline after trainers looked at his right knee. He was later carted to the locker room while the drive was winding up with Robert Meachem's touchdown catch.
Kreutz appeared to hurt his left leg in the first half, but coach Sean Payton declined to discuss their injuries after the game.
Despite the injuries, the Saints won 40-33 after a pair of fourth-quarter rallies.
Information from The Associated Press contributed to this report.