Griffin was full-go after being limited Wednesday and Thursday while recovering from a concussion suffered in last week's 24-17 loss to the Atlanta Falcons. The rookie quarterback has been subject to NFL-mandated post-concussion medical tests that he must pass before he can play.
"If he passes his tests and we don't see any symptoms, then it looks like he'll be ready to go," coach Mike Shanahan said.
Shanahan reiterated the final decision will be made by the medical professionals.
"That's what we have doctors for," the coach said. "Doctors make those decisions; we don't. ... That's why we run all these tests. But why would you not let somebody play if he's felt good right at the end of the game, every day until now? But if he has these tests after practice and all of sudden he's not feeling good or something's wrong, obviously we're not going to take the chance."
Griffin is officially listed as questionable on the injury report.
Shanahan was less optimistic about receiver Pierre Garcon, who is bothered by a sore right foot and is also listed as questionable. Shanahan said Garcon didn't take many snaps in practice Friday.
Garcon, who signed a five-year, $42.5 million contract in the offseason, has only eight catches this season.
"It's tender and it's still sore, but it's a pain issue," Shanahan said. "Not sore enough to where he can't push off all the time, so that's why we listed him as questionable."