Spikes, who said Thursday that he was anticipating a fine, was penalized on the play, which came with 10:36 remaining in the fourth quarter of the Patriots' 37-31 win. After the play, Fitzpatrick -- who had his helmet knocked off by the hit -- got in Spikes' space.
In addition, Patriots rookie cornerback Alfonzo Dennard was fined $7,875 for unnecessary roughness for a late hit on Fitzpatrick, which came out of bounds in the second quarter. And Pats linebacker Jerod Mayo, who tackled C.J. Spiller after the Bills' running back ran out of bounds, was fined $10,000 for the late hit.
The hit came in Indianapolis' victory Nov. 8 at Jacksonville and negated an interception by Aaron Ross.
Jaguars safety Dawan Landry was fined $10,000 for a fourth-quarter hit on Luck that made contact to the head and neck area after Luck declared himself down by sliding feet first.
Fined $21,000 on Friday were 49ers defensive lineman Ray McDonald for a helmet-to-helmet hit on Rams quarterback Sam Bradford last Sunday, and Minnesota linebacker Jasper Brinkley for a helmet hit on a defenseless Lions player.
Information from ESPNBoston.com's Mike Reiss and The Associated Press was used in this report.