Spiller, who was injured during Sunday's win over the Baltimore Ravens, said his ankle was less swollen than expected Monday and that his availability would be a game-time decision.
"I can't walk normally," he said. "It's a little sore. [But] it wasn't as swollen as we thought it was going to be. That's a good thing."
Running back Fred Jackson also was injured against Baltimore. He said he sprained his MCL, the same injury he suffered last season, but that this injury is "less significant" and he expects to play Thursday.
X-rays after the game revealed no structural damage to Spiller's ankle. He said that he will arrive at First Energy Stadium on Thursday earlier than normal to test his injury.
"I'll come in early and test it out, do some planting and see how it feels," he said.