CLEVELAND -- Buffalo Bills quarterback EJ Manuel, who left Thursday night's 37-24 loss to the Cleveland Browns in the second half with a sprained right knee, was scheduled to undergo an MRI on Friday, a source told ESPN NFL Insider Adam Schefter.
Coach Doug Marrone said Manuel's injury will be evaluated in the coming days. The Bills do not play again until Oct. 13 against the Cincinnati Bengals.
"I saw him working out on the sideline and thought we could get him back," Marrone said. "And then [the medical staff] shut him down."
Marrone said it was too early to say if the Bills will evaluate quarterbacks on the free-agent market if Manuel, the 16th overall pick in April's draft, must miss time.
On a third-down play in the third quarter, Manuel was pressured and scrambled for a first down. After gaining the necessary yardage, Manuel took a few more strides before being tackled along the sideline by Browns defensive back Tashaun Gipson.
"I'm sure the kid wanted to score a touchdown," Marrone said. "EJ's a tough kid. He took a shot. He got flushed out, he scrambled. What do you say? Don't scramble? Don't score a touchdown?"
Gipson said he wasn't trying to injure Manuel on the hit.
"First and foremost, it's the game of football. Things like that happen," Gipson said. "I definitely don't intentionally try to hurt anybody. I wouldn't dare do that. I'm not that kind of player.
"It's the game of football. Our QB took a shot. Their QB took a shot. Not to say that we were trying to go one for one, but it's the game of football. He's running around on the sidelines. He could have gotten out of bounds. He didn't. So it's my job to bring the ball carrier down."
Manuel was briefly down on the field but was able to walk to the bench. He was later seen jogging on the sideline before heading to the locker room.
Undrafted rookie Jeff Tuel replaced Manuel and went 8-of-20 passing for 80 yards, throwing a late interception that the Browns returned for a touchdown.
Tuel was slated to start in Week 1 if Manuel, who had knee surgery in August, wasn't ready for the start of the season. Even though Manuel returned in time, Tuel said that experience helped him Thursday night.
"I took all the reps and felt really comfortable with it. Felt like I had great weeks of practice as the guy," he said. "I know what the role is like, so it won't be the first time for me."
The Bills also lost top receiver Stevie Johnson to a back injury suffered in the second quarter.
Johnson had two catches for 19 yards before taking himself out of the game. He had been listed on the injury report as probable with a hamstring injury.
Information from ESPN Browns reporter Pat McManamon and ESPN Bills reporter Mike Rodak was used in this report.