"As coach would say, Murphy [Murphy's Law] is here, but the way you defeat Murphy is you just keep fighting, you keep playing, and we'll see how things turn out," running back Maurice Jones-Drew said. "There's no way in hell we're going to back down.
"We're going to go out there and play our game the same way we always have and we'll go out there and have fun."
The Jaguars (0-5), whose five losses have been by an average of 18.2 points, are 28-point underdogs to the Broncos (5-0) -- tying the largest point spread in NFL history. One of the biggest questions surrounding Sunday's game is whether the Broncos should sit quarterback Peyton Manning at halftime.
Manning is on a historic roll, and the Broncos have won 16 regular-season games in a row. His team leads the NFL in scoring and is averaging nearly 50 points a game.
And Vegas bookmakers aren't the only ones who think the Jaguars don't have a chance. SCA Promotions of Dallas has announced it'll donate $100,000 to the National Multiple Sclerosis Society if the Jaguars win -- or $100 per point if they don't.
But the Jaguars, who are last in the NFL in nine statistical categories, aren't accepting the fate that nearly everyone expects.
"I don't care about a point spread," wide receiver Cecil Shorts said. "That has nothing to do with the outcome of the game. That don't mean nothing to me. I don't want to hear about it.
"What's it have to do with football? What does whatever the spread is have to do with the outcome of the game? It doesn't have s--- to do with me at all, so I don't want to hear about it. No more questions about the point spread, please. That's dumb."
The Jaguars are actually riding a three-game winning streak against the Broncos. Denver hasn't beaten Jacksonville in more than eight years, winning 20-7 in Jacksonville on Oct. 2, 2005. The last time the Broncos beat the Jaguars in Denver was in 1998.