Landry's return couldn't come at a better time for the Colts, who will face the best offensive team in the league on Sunday.
Quarterback Peyton Manning, who spent his first 14 seasons in Indianapolis, has the Broncos (6-0) averaging league high in points (44.2), total yards (476) and passing yards (360.7). Manning has thrown for 22 touchdowns and just two interceptions and has been sacked only five times.
"Everybody knows Peyton," Landry said. "Great quarterback, one of the best. You really have to be sound in your coverage, give different looks, disguises. For us, it's all about what we create, what we do on the back end and just disguising and playing sound coverage.
"Peyton is going to be Peyton. He's going to make some plays, we have to respond."
The Colts (4-2), 11th in the league in defense, will have their starting unit together for the first time since Week 2 against Miami. Linebacker Jerrell Freeman, who missed the second half of Monday's game at San Diego with concussion, has been cleared to play.