"I just don't know right now," Johnson said Monday. "I need to get more work done, then we'll find out later in the week."
Johnson left in the fourth quarter of the Bills' 23-10 loss to the Pittsburgh Steelers. He caught three passes for 48 yards before departing.
This was the second time in three games Johnson has left with an injury, and just one of several times he has been hurt this season.
"[The groin injury] probably feels a little worse," he said. "It's one of those seasons where it seems like you get hurt on everything. It sucks. I'm probably doing more than I've done any other season, and I'm still having these wild injuries.
"It's happening on plays where we get positive yards. It's no fluke-type deal. It's just football."
Johnson has missed just one game this season and played in 16 games each of his previous two seasons.
A six-year veteran, Johnson has 41 catches for 471 yards and three touchdowns -- all team highs -- in nine games this season.
In addition to Johnson, the Bills could also be without rookie receiver Robert Woods for the second consecutive game. Coach Doug Marrone said Monday that he is leaning toward resting Woods, who has a high-ankle sprain, another week.
"I think we'll have to make a decision [on him]," Marrone said. "Whether we sit him this week and have him healthy for the next five games, or do we play him and take a chance of him not being available if he re-injures that ankle."