Wallace has been bothered this week by a hamstring injury and is listed as questionable on Miami's injury report.
Dolphins star center Mike Pouncey, who is listed as questionable because of an illness, also is expected to play against San Diego, a league source told ESPN.
Wallace was limited in practice Friday but is expected to suit up in a big game for the Dolphins (4-5), who have lost five of their past six games.
Wallace is second of the Dolphins with 40 receptions for 495 yards and a touchdown this season after signing a five-year, $60 million contract with Miami this past offseason.
Martin left the team on Oct. 28 following a lunch room incident, claiming Incognito bullied and harassed him.
Incognito has been suspended indefinitely by the Dolphins for conduct detrimental to the team. Backup offensive tackle Will Yeatman also suffered a significant knee injury on Wednesday and on Saturday was placed on injured reserve, the team announced.
ESPN NFL Insider Adam Schefter contributed to this report.