Source: Mike Iupati has MCL sprain
Get the latest NFL injury news
Who's out? Who's good to go? Who's questionable? We've got all the latest injury news from around the NFL. Injury Wire
Iupati was carted off to the locker room during the 49ers' 23-20 loss at New Orleans on Sunday. He was seen leaving the locker room on crutches and with his knee in a brace.
During the game, Iupati was replaced by Adam Snyder.
The 49ers' offense is struggling. It has not been able to cross the 200-total yard plateau in two straight games, and it had five three-and-outs Sunday.
Information from ESPN NFL Insider Adam Schefter and ESPN.com San Francisco 49ers reporter Bill Williamson contributed to this report.
THE NFL ON ESPN.COM
MORE NFL HEADLINES
- Nike Women's Home Limited Jersey San Francisco 49ers Patrick Willis #52