ScheduleAll times ET

2015 Schedule
2-1, 2nd in AFC East

Bills likely to go to 3-1?

In a rematch of Super Bowl XXV, ESPN's Football Power Index expects a different outcome this time. FPI sees the Bills as nearly 3-to-1 favorites over the Giants.

AP Photo/Lynne Sladky

Karlos Williams a must-start?

The exciting rookie will get the start against the Giants on Sunday in place of LeSean McCoy. Is there any way that Williams won't deliver? Fantasy cheat sheet (Insider)

Swami Sez: Week 4 picks (1:23)
Bills taking cautious approach with McCoy, Watkins (0:44)
ESPN Illustration

Most evenly bet game of the week

The public is split between Buffalo (-5) and New York. Does Dave Tuley believe the Bills' hype, or does he think the Giants are rounding into form? Tuley's bets (Insider)

Mike Rodak ESPN Staff Writer 

LeSean McCoy said Friday he suffered a setback with his hamstring injury last Thursday. "I kind of hurt it again. And that's where it went wrong. I tried to really push it. I guess I messed something up."

Mike Rodak ESPN Staff Writer 

LeSean McCoy says he won't play until he's 100 percent. Doesn't rule out sitting out more games.

Mike Rodak ESPN Staff Writer 

LeSean McCoy (hamstring) and Sammy Watkins (calf) have both been officially ruled out for the Bills' game Sunday against the New York Giants.

AP Photo/Lynne Sladky

Battle of the depth charts

Don't expect a repeat of Super Bowl XXV between Buffalo and New York this week. This game will feature the Bills' roster depth against the Giants' lack thereof. NFL Nation Week 4 predictions

Mike Rodak ESPN Staff Writer 

Sammy Watkins (calf) and LeSean McCoy (hamstring) did not practice Friday after also missing practice Wednesday and Thursday. The Bills will release their injury report around 1 PM Friday.

Brett Carlsen/Getty Images

Bills will lean on replacements

Karlos Williams, Percy Harvin and Robert Woods will have to carry the load with LeSean McCoy and Sammy Watkins looking doubtful for Week 4. How will the replacements perform? Week 4 fantasy advice (Insider)

2dBill Barnwell

Grantland: The Worst Plays in NFL History

Every season, someone does something that gets nominated as an historically bad play, but just what does it take to make the cut as one of the worst of the worst?

Bills are a playoff team (0:44)
Kirby Lee/USA TODAY Sports

Flags up by 1.2 per game in 1st 3 weeks over 2014

In 48 games over the first three weeks, according to STATS research, 878 penalties have been called. That's an average of 18.3 per game, up from 17.1 per game in the first three weeks of 2014.

Cousin Sal's Week 4 picks (3:05)
NFL Cold Hard Facts: Big names injured (2:11)
Gary Wiepert/AP

Cockcroft: Use Taylor vs. the Giants

Tristan H. Cockcroft says the Giants' defense has yet to face a quarterback this season with the kind of mobility that Tyrod Taylor brings to the table. Good Week 4 matchups (Insider)

What you need to know for Week 4 (1:05)
Photo by Brett Carlsen/Getty Images

Stepping out from the shade

With LeSean McCoy nursing a hamstring injury, Karlos Williams should get all the work. The rookie back has been Buffalo's most reliable runner. Berry: Love/Hate

Who to draft for Week 4? (1:25)

Team Stats

Passing Yards220.324th
Rushing Yards152.71st
Points For33.33rd
Points Against22.7Tied-13th

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