Massaquoi caught the first pass rookie Brandon Weeden threw Friday night, then was ruled out for the rest of the game before the first quarter ended.
The fourth-year pro was limited the past two seasons because of concussions. Massaquoi left a game last year in October against Seattle with a concussion.
Massaquoi had career lows last season with 31 receptions and 384 yards receiving. The former Georgia standout has 101 career receptions for 1,491 yards and seven touchdowns.