"It's real simple: We're going to give him the ball until he throws up," Hackett told The Howard Simon Show on WGR 550 in Buffalo. "So he's either got to tap out or throw up on the field. Let's just put it that way."
Spiller was one of the most efficient running backs in the NFL last season, gaining 1,244 yards on 207 carries. His 6.0 yards per carry was tied with the Minnesota Vikings' Adrian Peterson as an NFL-best among running backs with at least 6.25 attempts per team's games played.
"The great thing now is that we have some awesome weapons on the outside [at wide receiver], if you do want to stop [Spiller]," Hackett said.
Hackett, 33, is in his first season as an NFL coordinator, having previously served under Bills coach Doug Marrone at Syracuse. The Bills are adopting an up-tempo, no-huddle offense that Hackett installed at Syracuse.
"Switching to this system and the tempo we've created, it's a completely different way that we call the game," Hackett said. "It's more of an attacking thing, and you get to put pressure on the defensive coordinator."
Since Spiller was drafted ninth overall in 2010, he has shared the Bills' backfield with Fred Jackson. But Spiller nearly doubled his carries last season when Jackson was limited by a knee injury.