| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Tom Brady |
1. Tom Brady, QB | NWE | W 25-24 vs. BUF | 39 | 53 | 378 | 2 | 1 | 1 | 0 | 97.8 |
| 2. Ben Roethlisberger, QB | PIT | W 13-10 vs. TEN | 33 | 43 | 363 | 1 | 2 | 4 | 0 | 89.6 | |
| 3. Drew Brees, QB | NOR | W 45-27 vs. DET | 26 | 34 | 358 | 6 | 1 | 0 | 0 | 137.0 | |
| 4. Tony Romo, QB | DAL | W 34-21 at TAM | 16 | 27 | 353 | 3 | 0 | 1 | 0 | 140.6 | |
| 5. Joe Flacco, QB | BAL | W 38-24 vs. KAN | 26 | 43 | 307 | 3 | 1 | 1 | 0 | 95.8 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Adrian Peterson |
1. Adrian Peterson, RB | MIN | W 34-20 at CLE | 25 | 180 | 7.2 | 3 | 64 | 0 | |
| 2. Mike Bell, RB | NOR | W 45-27 vs. DET | 28 | 143 | 5.1 | 0 | 22 | 1 | ||
| 3. Julius Jones, RB | SEA | W 28-0 vs. STL | 19 | 117 | 6.2 | 1 | 62 | 0 | ||
| 4. Ray Rice, RB | BAL | W 38-24 vs. KAN | 19 | 108 | 5.7 | 0 | 22 | 0 | ||
| 5. Thomas Jones, RB | NYJ | W 24-7 at HOU | 20 | 107 | 5.4 | 2 | 39 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Reggie Wayne |
1. Reggie Wayne, WR | IND | W 14-12 vs. JAC | 10 | 162 | 16.2 | 1 | 39 | 0 | |
| 2. Randy Moss, WR | NWE | W 25-24 vs. BUF | 12 | 141 | 11.8 | 0 | 31 | 0 | ||
| 3. Patrick Crayton, WR | DAL | W 34-21 at TAM | 4 | 135 | 33.8 | 1 | 80 | 0 | ||
| 4. Santonio Holmes, WR | PIT | W 13-10 vs. TEN | 9 | 131 | 14.6 | 1 | 34 | 0 | ||
| 5. Tim Hightower, RB | ARI | L 20-16 vs. SFO | 12 | 121 | 10.1 | 0 | 23 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
London Fletcher |
1. London Fletcher, LB | WAS | L 23-17 at NYG | 11 | 7 | 18 | 0.0 | 0 | 0 | 0 |
| 2. Thomas Davis, LB | CAR | L 38-10 vs. PHI | 14 | 2 | 16 | 0.0 | 0 | 0 | 0 | |
| 3. Keith Ellison, LB | BUF | L 25-24 at NWE | 11 | 5 | 16 | 0.0 | 0 | 0 | 0 | |
| 4. Patrick Willis, LB | SFO | W 20-16 at ARI | 12 | 2 | 14 | 0.0 | 0 | 1 | 0 | |
| 5. James Laurinaitis, LB | STL | L 28-0 at SEA | 10 | 4 | 14 | 0.0 | 0 | 0 | 0 | |