| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Eli Manning |
1. Eli Manning, QB | NYG | L 49-24 at NO | 33 | 47 | 406 | 2 | 1 | 1 | 0 | 101.9 |
| 2. Vince Young, QB | PHI | L 38-20 vs. NE | 26 | 48 | 400 | 1 | 1 | 2 | 0 | 80.2 | |
| 3. Drew Brees, QB | NO | W 49-24 vs. NYG | 24 | 38 | 363 | 4 | 0 | 0 | 0 | 129.6 | |
| 4. Tom Brady, QB | NE | W 38-20 at PHI | 24 | 34 | 361 | 3 | 0 | 1 | 0 | 134.6 | |
| 5. Rex Grossman, QB | WSH | W 23-17 at SEA | 26 | 35 | 314 | 2 | 2 | 1 | 0 | 96.6 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Beanie Wells |
1. Beanie Wells, RB | ARI | W 23-20 at STL | 27 | 228 | 8.4 | 1 | 71 | 1 | |
| 2. Chris Johnson, RB | TEN | W 23-17 vs. TB | 23 | 190 | 8.3 | 0 | 34 | 1 | ||
| 3. Ryan Mathews, RB | SD | L 16-13 vs. DEN | 22 | 137 | 6.2 | 0 | 39 | 0 | ||
| 4. Willis McGahee, RB | DEN | W 16-13 at SD | 23 | 117 | 5.1 | 0 | 24 | 0 | ||
| 5. Marshawn Lynch, RB | SEA | L 23-17 vs. WSH | 24 | 111 | 4.6 | 0 | 12 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Victor Cruz |
1. Victor Cruz, WR | NYG | L 49-24 at NO | 9 | 157 | 17.4 | 2 | 72 | 0 | |
| 2. Johnny Knox, WR | CHI | L 25-20 at OAK | 4 | 145 | 36.3 | 1 | 81 | 0 | ||
| 3. Deion Branch, WR | NE | W 38-20 at PHI | 6 | 125 | 20.8 | 0 | 63 | 0 | ||
| 4. Reggie Wayne, WR | IND | L 27-19 vs. CAR | 5 | 122 | 24.4 | 1 | 56 | 0 | ||
| 5. Roddy White, WR | ATL | W 24-14 vs. MIN | 10 | 120 | 12.0 | 1 | 26 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Chad Greenway |
1. Chad Greenway, LB | MIN | L 24-14 at ATL | 7 | 9 | 16 | 0.0 | 0 | 0 | 0 |
| 2. Takeo Spikes, LB | SD | L 16-13 vs. DEN | 8 | 6 | 14 | 0.0 | 0 | 0 | 0 | |
| 3. Perry Riley, LB | WSH | W 23-17 at SEA | 6 | 8 | 14 | 0.0 | 0 | 0 | 0 | |
| 4. Kevin Burnett, LB | MIA | L 20-19 at DAL | 11 | 1 | 12 | 0.0 | 0 | 0 | 0 | |
| 5. Kurt Coleman, S | PHI | L 38-20 vs. NE | 11 | 1 | 12 | 0.0 | 0 | 0 | 0 | |
